DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arts and tnpo2

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001004003.1	Gene:	tnpo2 / 445499	ZFINID:	ZDB-GENE-040822-16	Length:	889	Species:	Danio rerio

Alignment Length:	935	Identity:	181/935 - (19%)
Similarity:	337/935 - (36%)	Gaps:	279/935 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILDIINGILAIDTERIRESTAKMLKAYENPD----SLLVLTQIVMSDRPVQERQVAAVLLKRRVK 65
            :|.::....:.:|...|....|:.:..:.||    .:.|||::...|.|.  |.::.::||..||
Zfish    13 VLQLLRDSQSPNTATQRAVQQKLEQLNQFPDFNNYLIFVLTRLKTEDEPT--RSLSGLILKNNVK 75

  Fly    66 KLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYER 130
            .  |:|..|......||...|. .|......::.|:..:|.::  ..:.:..:|.|    .:.:.
Zfish    76 V--HYQNFPPAVAHFIKQECLN-NIGDPSPLIRATIGILITTI--STKGELQTWPE----LLPQL 131

  Fly   131 CSSPDPIESERGSSIFSSLMDAAPD----------------------QFSNHTDTIFPLLAGILV 173
            |:..|..:.......|.:|.....|                      ||..|
Zfish   132 CNMLDSEDYNICEGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKH------------- 183

  Fly   174 TAEANGNMATPTVHNMLAGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFD 238
                    .:|.:.:. |..||....||    ..|.::..:...:::|.|.:...:|........
Zfish   184 --------CSPKIRSH-AVACVNQFIIS----RAQALMDNIDTFIESLFALSSDEDSEVRKNVCR 235

  Fly   239 IIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTF--------------VGSLVRL 289
            .:..:.|.....|..:::.::|:  |:.|.:..|.::.::...|              .|.|.:|
Zfish   236 ALVMLLEVRVDRLLPHMRSIVEY--MLQRTQDPDENVSLEACEFWLTLAEQPICKDVLSGHLAQL 298

  Fly   290 KKKIIMKQKLLQPTLSVLFEVICQD--------DLK-------------------EG-------- 319
            ...::...|..:..:.:|...:.:|        |:|                   ||
Zfish   299 VPVLVNGMKYSEIDIILLKGDVEEDEAVPDNEQDIKPRFHKSRTVTLRHEGDEGEEGEDSEDDDD 363

  Fly   320 -DDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIA 383
             |||..|..:|...|.||   ||::| ::..|:.:|.||.:|:..|..|:.|::.|..:.:|.||
Zfish   364 DDDDSLSDWNLRKCSAAA---LDVLA-NVFRDELLPHLLPVLKELLFHPDWVVKESGILVLGAIA 424

  Fly   384 EGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFL--QPTICKFAPQILPVLFDY 446
            |||.:.:.....|::.::::. :.|....||:.|.:.|.:::.::  ||.            ..|
Zfish   425 EGCMQDMVLYLPELIPHLVQC-LCDKKALVRSIACWTLSRYAHWVVSQPA------------DSY 476

  Fly   447 LNQLVLEL--KVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLF--------------- 494
            |..|:.||  ::.:.:.|..:....|..|..|....::||||..::|.|.
Zfish   477 LKPLMTELLKRILDSNKKVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFSKYQHKNLLILY 541

  Fly   495 ---------------------GVMEP--QNSNQMRE------MALSAIAAVSAAAKENLMPY--- 527
                                 .:|.|  |..|::::      ..|..:::|:.|.:...:||
Zfish   542 DAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEP 606

  Fly   528 -FPRIMTVLQGCLVKDCPKEMYSQR------------IQAIDTLAALCRELG--------KDNII 571
             :.|.:|::|..|.:   ..||:|:            |.|:|.|:.|...||        :.||:
Zfish   607 VYQRCVTLVQKNLAQ---AMMYNQQPEQYEAPDKDFMIVALDLLSGLAEGLGANVEQLVTRSNIM 668

  Fly   572 PLADETMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSV--------VNESM----ASVFPKFIDRI 624
            .|..:.|...:         ||.|:|.:.|:..|:..        |.|.|    .::.|:||...
Zfish   669 TLLFQCMQDTM---------PEVRQSSFALLGDLTKACFLHVKPCVAEFMPVLGLNLNPEFISVC 724

  Fly   625 MESVISSEDMVPNVSDNAEDDLALVDAPDIEID---------LEHTDDEDDQDAYLGENDYIVEK 680
            ..:..:..::...:....:..:|||....:||.         ||:|      ...:|...|:..:
Zfish   725 NNATWAIGEITMQMGTEMQPFVALVLNNLVEIINRPNTPKTLLENT------AITIGRLGYVCPQ 783

  Fly   681 EEAILSLKEFATHTGAAFAPYL------------QSAFENVYKMID-HPQG---DVRMACIDSIC 729
            |.|.: |.:|       ..|:.            .|||..:..||. :|.|   |....| |::.
Zfish   784 EVAPM-LPQF-------IRPWCTSLRNIRDNEEKDSAFRGICVMIGVNPGGVVQDFIFFC-DAVA 839

  Fly   730 SFIT-----------ALHKLDDAAG 743
            |::|           .||...|..|
Zfish   840 SWVTPKDDLRDMFYKILHGFKDQVG 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	18/64 (28%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	7/36 (19%)
tnpo2	NP_001004003.1	IBN_N	32..99	CDD:281761	20/71 (28%)
		HEAT repeat	93..114	CDD:293787	4/21 (19%)
		ARM	125..240	CDD:237987	19/144 (13%)
		HEAT repeat	127..155	CDD:293787	4/27 (15%)
		HEAT repeat	165..202	CDD:293787	7/58 (12%)
		HEAT repeat	213..239	CDD:293787	3/25 (12%)
		HEAT_EZ	228..275	CDD:290247	6/48 (13%)
		HEAT repeat	252..281	CDD:293787	5/30 (17%)
		HEAT repeat	397..425	CDD:293787	9/27 (33%)
		HEAT_2	398..502	CDD:290374	26/116 (22%)
		HEAT_EZ	410..464	CDD:290247	14/54 (26%)
		HEAT repeat	437..467	CDD:293787	6/30 (20%)
		HEAT repeat	476..505	CDD:293787	7/28 (25%)
		HEAT repeat	667..695	CDD:293787	9/36 (25%)
		HEAT repeat	707..737	CDD:293787	5/29 (17%)
		HEAT repeat	748..776	CDD:293787	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910