DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Karybeta3

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	1195	Identity:	259/1195 - (21%)
Similarity:	501/1195 - (41%)	Gaps:	236/1195 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EAAILDIINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQE----RQVAAVLLKR 62
            :|....::..:|:.|.: :|:...   :||.|....|.:|.::.:.:..|:    ||:|||||:|
  Fly     5 QAHFQQLLASLLSTDND-VRQQAE---EAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRR 65

  Fly    63 --RVKKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKT---VKGTVAFIIGSLVRH--EEDKQNSWR 120
              ..:....::.:|||.|..:   :.|:|:||:::.   ::..:..::..:.|:  :||..|.|
  Fly    66 LFTTEFFDFYKGLPAESQNQL---LQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQW- 126

  Fly   121 EEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPT 185
            .:||:|:::..:||.|...|....||||:.....:|.:.:.|.|..:||
  Fly   127 PDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLA---------------- 175

  Fly   186 VHNMLAGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFA---EKGN------------------ 229
             .:|.||           ||.| :.|:||    :|:.||.   :|.|
  Fly   176 -KSMDAG-----------SDPE-VRVQAV----RAVGAFILYHDKENETAIHKHFADMLPRMIHI 223

  Fly   230 SNEFMGAFD------IIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVR 288
            :.|.:.|.|      ::..|.|..|..|...::.:.|.|:.:..::.|:.|.|..||..:.||..
  Fly   224 TGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE 288

  Fly   289 LKKKIIMKQ--KLLQPTLSVLFEVICQDDLKEGDDDYFSSESL-----NSPSNAAAQ-TLDLMAL 345
            ....:|.|:  |.:...:.::..::...|    ||:.:|:..:     :|.:|..|: :||.:|.
  Fly   289 NAPSMIRKRADKYIVALIPLILHMMTDLD----DDENWSTADVVDDDDHSDNNVIAESSLDRLAC 349

  Fly   346 HMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL--- 407
            .:.....:|.:::.|...|...:...|.::.:.:..|.|||     .|.:|.:|:.:.:|||
  Fly   350 GLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC-----HKQMEAILDEVMSGVLNFL 409

  Fly   408 -DSVMFVRTAAFFALGQFS-EFLQPTICKFAPQILPVLFDYLNQLV---LELKVGEPDSKHMDRM 467
             |....||.||..|:||.| :|.|....||..|::|.|...|:.:.   ::...|.
  Fly   410 SDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGA--------- 465

  Fly   468 FYALETFCENLDEDIVP-YLPTLMDRL-------FGVMEPQNSNQMREMALSAIAAVSAAAKENL 524
              ||..|.|:..::|:. ||..:|.:|       |..:..:.:..:.|..::.||:|:...:...
  Fly   466 --ALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCESEF 528

  Fly   525 MPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDG- 588
            :.|:.|:|..|:..:......::...|.:.|:.::.:...:|::..|..|.|.|:..|:...:|
  Fly   529 VAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGG 593

  Fly   589 ---PDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVD 650
               .|||: ...:....:.:..::.:.    |.:::..:|..|:.:..|.|.|        |::|
  Fly   594 ELADDDPQ-TSYLITAWARMCKILGKQ----FEQYLPLVMGPVMRTATMKPEV--------AMLD 645

  Fly   651 APDIEIDLEHTDDEDDQDAYLGENDYIV-------EKEEAILSLKEFATHTGAAFAPYLQSAFEN 708
            ..::| |::  .|.|.....|||.....       :|..|...|..:|......||.|.:.....
  Fly   646 NDEVE-DID--GDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQ 707

  Fly   709 VYKMIDHPQGD-VRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRML 772
            :..|:.....| ||.|..:|: .::....|:.....|:.......|:...::.|:.:..|...:|
  Fly   708 MLPMLKFYFHDGVRTAAAESL-PYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELL 771

  Fly   773 DVL-------------YDVFKYVPAINSQ---EHAELIFGCIRDIFTNKMACQFNEE--SGGGDD 819
            :.|             .|..|.|..|.::   ||.|.         .:|.....|||  ..|.::
  Fly   772 NSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFER---------ADKRLAARNEEDYDDGVEE 827

  Fly   820 ECSEESEND-----------EMLFE-NAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKER 872
            |.:|:.:.|           ..||: |.|...|.|      |..:.:|.:|    ::....|.:|
  Fly   828 ELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAF------EQVAPHFVKL----LEPSRPVADR 882

  Fly   873 DLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEI-VFHSEEK 936
               :....::..|.:.|..   .||.|.....|..:....|...:.||.:.:..|.: .|..|:.
  Fly   883 ---QWGLCVFDDLIEFCGP---ACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQF 941

  Fly   937 SF---ESYPTILQALSEAIVRE-SVPAAMDNICGAVARLIVTNPDSVP-LGQVLPVWLNHLPLKD 996
            :.   :..|.::|.:::...|| ...:..:|...|.|:::..|..::. :.:::.||.:.||:.:
  Fly   942 AHTCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSE 1006

  Fly   997 DTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESA----- 1048
            |:.|.        |:|:....|: |.|.   ..:|.:|::|..|:...|    |...:||
  Fly  1007 DSEEAAHIYGYLCDLIEGNHPVI-LGAN---NGNLPRIVSIIAESFCTK----VVEAQSATGTRM 1063

  Fly  1049 VALIKEIRANYPELFSK-VSNMNPE 1072
            :.::|::.:| ||:.:. .|.::||
  Fly  1064 LTIVKQVESN-PEVMAACASTLSPE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/66 (29%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	13/34 (38%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	18/83 (22%)
		HEAT repeat	235..261	CDD:293787	4/25 (16%)
		HEAT repeat	272..305	CDD:293787	9/32 (28%)
		HEAT repeat	357..385	CDD:293787	4/27 (15%)
		HEAT_2	364..467	CDD:290374	31/118 (26%)
		HEAT_EZ	373..427	CDD:290247	18/58 (31%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		ARM	405..503	CDD:237987	30/108 (28%)
		HEAT repeat	442..473	CDD:293787	8/41 (20%)
		HEAT repeat	485..519	CDD:293787	5/33 (15%)
		HEAT repeat	532..565	CDD:293787	5/32 (16%)
		HEAT repeat	867..894	CDD:293787	5/33 (15%)
		HEAT repeat	906..936	CDD:293787	5/29 (17%)
		HEAT repeat	947..979	CDD:293787	6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790