DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and imb-3

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_490715.1	Gene:	imb-3 / 3565440	WormBaseID:	WBGene00002077	Length:	1092	Species:	Caenorhabditis elegans

Alignment Length:	1149	Identity:	240/1149 - (20%)
Similarity:	462/1149 - (40%)	Gaps:	147/1149 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DIINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRH-- 69
            ::|..:.:.|.: ||:...::.:..|.|..:..|.:.........:.:...::..|||  |..
Worm     8 ELITKLQSADND-IRKQAEEVYEKIEGPTKVAALFEAYTHHTNNSDARSTVLVFLRRV--LARDW 69

  Fly    70 ---WQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYE 129
               |:.:..|::..|.:.:|::::...|.::|..:|.:|..:..:  ::....:| ..:|: :.:
Worm    70 DAIWETLNEENKQRILAKVLEMIVHETELSIKKKIADLISEIASNLIDDSGDMTW-GGVLE-LMD 132

  Fly   130 RCSSPDPIESE--RGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAG 192
            .|     ::||  .|:.|...::...|..|.|......|.|..:|...     ||||.:......
Worm   133 HC-----LKSEDLTGNYIALLILRGCPIIFGNRLAHFLPTLKVVLEKC-----MATPDLQIKATA 187

  Fly   193 TCVLLPFI---SGHSDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGN 254
            ...::.|.   ....|..::|...||.:|:.....:::.:|:..:|.|   ..:|..:|..|..:
Worm   188 VRAVIAFAVDNDEEKDVVRLMTSLVPNVLQVCNETSDEDDSDGPLGEF---AELASSLPKCLNTH 249

  Fly   255 VKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQK--LLQPTLSVLFEVICQDDLK 317
            :..:|:..|.||.||:.:..:|...:..:.|.:....|.:.|..  .|.|.|..|..  |   :.
Worm   250 MSQVLQVTLAIAGNKEKNEMVRQNAIEVICSYMESAPKGLKKYAPGALGPILETLLS--C---MT 309

  Fly   318 EGDDDYFSSESLNSPSN---------AAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRR 373
            |.|||.. :|.||....         .|...:|.:|..:.....:|..|.|:|..|.|.:..::.
Worm   310 EMDDDVL-NEWLNEIEEEEDYEDIPIIAESAIDRVACCINGKVMLPVFLPLVEKLLTSEDWKMKH 373

  Fly   374 SSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTI---CKF 435
            ::......:.|||..:: :.::|.::..|...|.|:...|:.||..|:||.|....||:   |..
Worm   374 AALRAFSAVGEGCQRSM-EPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCHA 437

  Fly   436 APQILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIV-PYLPTLMDRL------ 493
            |  ::|.|.:.|::..:........|        ||..|.|...:.|: .|||.::.:|
Worm   438 A--VIPALLESLDRTDVPRVCAHAAS--------ALVNFAEECPKSIIGQYLPFILQKLENVLSA 492

  Fly   494 -FGVMEPQNSNQMREMALSAIAAVSAAA----KENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQ 553
             |..:..:....:.|..::|||:|:.||    ||:.....|.::.:||..      .|:...|.:
Worm   493 VFNRLGDKRYQVVVENIVTAIASVAEAAEELFKEHHARLIPNLVHILQNV------GELKELRGK 551

  Fly   554 AIDTLAALCRELGKDNIIPLADETMNFCLMMLEDGP-----DDPEFRRSIYNLMSSLSSVVNESM 613
            .|:.::.:...:||:.....|.|.:|    :|.||.     |||::...| :..:...|::....
Worm   552 TIECISLIGYAVGKEQFHATAIEILN----LLGDGMKDLAIDDPQYSYMI-SSWTRFCSILGADF 611

  Fly   614 ASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDY-- 676
            |...|..:|.::.:.....|.  |:.:|.              |:...::..:.....||...
Worm   612 APFLPVVMDPVLRAARYRPDF--NIFNNE--------------DVHENEEGVEYHGIGGEKTVGI 660

  Fly   677 ----IVEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGD-VRMACIDSICSFITALH 736
                :.||..|...|..||.....||.||:...:|...|.:|....| ||.|..:.:...:|.:.
Worm   661 RTSGLEEKATACDMLVAFAKEMKEAFMPYVVDVYELAIKNLDFGLHDGVRTASAEIMPCLLTCVE 725

  Fly   737 KLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAIN-SQEHAELIFGCIRD 800
            |...|...:..||. :......|..:|.|.::...:..:....:.:.... ::|..:||...:..
Worm   726 KQGLADKRRLWCEF-LKALTTSMEEEDDVEILASFMTTIGSCIEVMKTEGIAEEEVQLIISVLLK 789

  Fly   801 IFTN---KMACQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLT--LQPELFSLYFGRLYH 860
            ...|   :|:.:..|:.  .||:...:.|.|..:...|:.|..:..||  |..|.....|..:.:
Worm   790 QLENYGKRMSDRPVEDE--DDDDAEAKEELDYFMELEASCLGAISDLTHSLMKEFKGTIFEGMIN 852

  Fly   861 FYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFA 925
            .:...:..::......:|.:....|.|..:...|...|.|..|.||......|...:.||.:.:.
Worm   853 VFNCAIQLIEGSKQYFERQWGMCLLDDAIEFGVGHMPTRFPKLIPIMYKLLGDEYPEVRQAASYG 917

  Fly   926 LG--EIVFHSEEKSFESYPTILQALSEAIVRESVPA------AMDNICGAVARLIVTNPDSVPL- 981
            .|  .|.:|..........:.|:.|:..|.||...|      |.:|...|.|::|    .:|||
Worm   918 FGVMAINYHQISDYRNEILSCLEPLAAMIQREDARATEESTVATENAISAFAKII----GNVPLP 978

  Fly   982 ----GQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSI----EAHLEQILAITI----EAS 1034
                |:|:.::|:.||...||.|:..|......|:.|...::    ..:|.:|..:.:    ..:
Worm   979 AEAYGKVVEMFLSWLPTYSDTEESPYIYTCLAELFDKQDAALFGPENQNLPRIFLVCLLSIANDA 1043

  Fly  1035 YKKQMPDVETTESAVALIKEIRANYPELFSKVSNMNPEVFNYVQ 1078
            :.......:|.:..|.::|:|.|::|: |::...::..:.:.:|
Worm  1044 FNDDDSGNQTKQRIVTILKQIYASFPQ-FAQQDGIDEHLTSVLQ 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	11/65 (17%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	10/29 (34%)
		HEAT repeat	438..473	CDD:293787	6/34 (18%)
imb-3	NP_490715.1	KAP95	<218..>486	CDD:227540	67/287 (23%)
		HEAT repeat	249..283	CDD:293787	8/33 (24%)
		Importin_rep_4	263..354	CDD:376227	21/96 (22%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	396..426	CDD:293787	10/29 (34%)
		HEAT repeat	438..465	CDD:293787	7/36 (19%)
		HEAT repeat	526..559	CDD:293787	7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760