DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Fs(2)Ket

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	175/928 - (18%)
Similarity:	311/928 - (33%)	Gaps:	278/928 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DIINGILAIDTERIRESTAKMLKAYEN----------PDSLLVLTQIVMSD-RPVQERQVAAVLL 60
            ||...::||..:.:.....::|.| :|          |:.|..|::|:::. .....|..|.:.|
  Fly     4 DIAMQLIAILEKTVSPDKNELLSA-KNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQL 67

  Fly    61 KRRV----KKLR-----HWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQ 116
            |..:    :|:.     .|...|:|.:..||:|   :|.|:..:..:.:.|....:.|...|...
  Fly    68 KNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNN---ILAALGTENTRPSCAAQCVAYVAVIELPI 129

  Fly   117 NSWREEILKFIYERCSSPDPIESERGSS------IFSSLMDAAPDQFSNHTDTIFPLLAGILVTA 175
            |.| ..:::.:..:..|....|..|.|:      |...:.....:..||  |.:..::.|:
  Fly   130 NRW-PMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSN--DVLTAIIHGM---- 187

  Fly   176 EANGNMATPTVHNMLAGTCVL---LPFISGHSDAE-------------------QIMVKAVPLIL 218
                ....|:.|..||.|..|   |.|...:.:.:                   ||.|.|:..::
  Fly   188 ----RKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLV 248

  Fly   219 KALAAFAEKGNSNEFMGAFDII--------DSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASI 275
            |.:..:.:..........|.|.        |::|      |.|     :||...:. :::.|.:|
  Fly   249 KIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVA------LQG-----IEFWSNVC-DEEIDLAI 301

  Fly   276 RVQVLTFVGSLVRLKKKIIMKQKL--LQPTLSVLFEVICQDDLKEGDDDYFSSESLNSPSNAAAQ 338
            ..|..|..|...:...|...:..|  |.|   ||.|.:.:.|  |.||     |...||:.||:.
  Fly   302 ESQEATDQGRAPQRVSKHYARGALQFLTP---VLVEKLTKQD--ECDD-----EDTWSPAKAASV 356

  Fly   339 TLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIK 403
            .|.::|. ...|:.:|.:|..::..::||....|.::.:..|.:..|......|..:|..:..:.
  Fly   357 CLMVLAT-CCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLI 420

  Fly   404 AGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQ------ILPVLFD-YLNQLVLELKV----- 456
            ..:.||.:.||....:..|:        ||...|:      .|..|.: ::..|..|.:|
  Fly   421 RLMYDSSVIVRDTIAWTFGR--------ICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVC 477

  Fly   457 ------------------GE-PDSKHMDRMF-YALETFCENLDE-----------------DIVP 484
                              || |::..:...| |.:....|..|.                 |::.
  Fly   478 WAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIK 542

  Fly   485 YLP------------TLMDRLFGVMEPQNS----------NQMREMALSAIAAVSAAAKENLMPY 527
            ..|            .:::||..||:.:..          |.::.:..:.:.:|.....|...|.
  Fly   543 NSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQ 607

  Fly   528 F-PRIMTVLQGCLVKDCPKE--MYSQRIQAIDTLAAL---------------------------- 561
            . ..|||.|.........|.  :..:...|:.||..|
  Fly   608 ISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQV 672

  Fly   562 -CRELG---------KDNIIPLADETMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASV 616
             |..:|         ||.::|.::|.|.    :|.:...:|...|::...:.|....:..|:.:.
  Fly   673 CCAAVGLTGDIFRALKDLMVPYSNEIMT----VLINNLTEPTIHRTVKPQVLSAFGDIALSIGNH 733

  Fly   617 FPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKE 681
            |..::..::       ||: .|:.|.:.|....|.                      |:||.|..
  Fly   734 FLPYLSMVL-------DML-RVASNLQTDANNFDM----------------------NEYINELR 768

  Fly   682 EAILSLKEFATHTG--AAFAPYLQSAFENVYKMIDH------------PQGDVRMACIDSICSFI 732
            |:||.     .:||  .......|:|..:|..|..|            .:|||..:.:.|...||
  Fly   769 ESILE-----AYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFI 828

  Fly   733 TAL---------HKLDDA 741
            ..|         ..||||
  Fly   829 GDLCTSFGPRLYPLLDDA 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/80 (21%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	10/66 (15%)
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	171/915 (19%)
		IBN_N	27..107	CDD:281761	19/83 (23%)
		HEAT repeat	136..162	CDD:293787	4/25 (16%)
		HEAT repeat	179..209	CDD:293787	7/37 (19%)
		HEAT repeat	223..255	CDD:293787	5/31 (16%)
		HEAT repeat	264..291	CDD:293787	8/37 (22%)
		HEAT repeat	330..360	CDD:293787	14/39 (36%)
		HEAT repeat	373..401	CDD:293787	5/27 (19%)
		HEAT_EZ	386..441	CDD:290247	10/62 (16%)
		HEAT repeat	414..444	CDD:293787	7/37 (19%)
		HEAT repeat	457..482	CDD:293787	4/24 (17%)
		HEAT repeat	508..540	CDD:293787	4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940