DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Ranbp6

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001101054.1	Gene:	Ranbp6 / 309326	RGDID:	1305165	Length:	1105	Species:	Rattus norvegicus

Alignment Length:	1135	Identity:	235/1135 - (20%)
Similarity:	466/1135 - (41%)	Gaps:	155/1135 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KAYENPDSLLVLTQIVMSDR----PVQERQVAAVLLKRRVKK--LRHWQLVPAEHQAAIKSNMLQ 87
            :.|||...|...|.::.:.|    ..:.||:||.||:|.:..  ...:..:|:|.|..:|   ::
  Rat    39 EVYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPSEVQRDVK---IE 100

  Fly    88 VLIAVKEKT---VKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYERCSSPDPIESERGSSIFS 147
            :::|||.:|   ::..:..|...|.|:  :|:..|.|.|. |||:.:...|.:.:..|....:|.
  Rat   101 LILAVKLETHASMRKKLCDIFAVLARNLIDENGTNHWPEG-LKFLIDSIHSKNVVLWEVALHVFW 164

  Fly   148 SLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVL-----LPFISGHSDAE 207
            .......:|..:..|.|..||...:...|   :.|..|:....|...||     :......:|
  Rat   165 HFPGIFGNQDRHDLDIIKRLLDQCIQDQE---HPAIRTLSARAAAAFVLANENNIALFKDFAD-- 224

  Fly   208 QIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFC----LMIARN 268
                 .:|.||:|:.....:.:.:......:|.|::.:|:...|...::|.|:.|    |   .|
  Rat   225 -----LLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRL---SN 281

  Fly   269 KQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDD----DYFSSESL 329
            .|...::.|.|.....:...|||...:..:.:...|:::.      ||::.||    |....:..
  Rat   282 LQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMV------DLQDDDDWVNADEMEEDDF 340

  Fly   330 NSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKY 394
            :|.:.||...||.:|..:.....:|...:.:...|||.:...|.:..:.:..|.|||.:.: :..
  Rat   341 DSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSHDWKCRHAGLMALSAIGEGCHQQM-EPI 404

  Fly   395 LEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEP 459
            |:..:|.:...:.|....||.||...|||.:       ..|||.......:.:...:|.....:.
  Rat   405 LDETVNSVLLFLQDPHPRVRAAACTTLGQMA-------TDFAPSFQKKFHEIVITALLRTMENQG 462

  Fly   460 DSKHMDRMFYALETFCENLDED-IVPYLPTLMDRLFGVMEPQNSNQMR-------EMALSAIAAV 516
            :.:...:...||..|.|:..:. ::.||..::..|..::..:....:|       |..::.||:|
  Rat   463 NQRVQSQAASALVIFIEDCPKSLLILYLENMVKSLQSILVIKLQELIRNGTKLALEQLVTTIASV 527

  Fly   517 SAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFC 581
            :...:||.:||:...|..|:..:.....||:...|.:.|:.::.:...:||:..:..|...|...
  Rat   528 ADVIEENFIPYYDIFMPSLKHVVELAVQKELKLLRGKTIECISHVGLAVGKEKFMQDASNVMQIL 592

  Fly   582 LMMLED----GPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNA 642
            |....|    ..|||:     .:.|.|..:.:.:.:...|.:::..::|.:|.:.        :|
  Rat   593 LKTQSDLNNMEEDDPQ-----TSYMVSAWARMCKILGKDFEQYLPLVIEPLIKTA--------SA 644

  Fly   643 EDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAF- 706
            :.|:||:|..|:|   ..:|||..|...||:......|... |..|..|......:|..|:..|
  Rat   645 KPDVALLDTQDVE---NMSDDEGWQFVNLGDQQSFGIKTSG-LEAKATACQMLVYYAKELREGFV 705

  Fly   707 ---ENVYKMI-----DHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDD 763
               |.|.||:     .:...:||||..::: .|:....::..:..|.:..:.........:.|:.
  Rat   706 EYTEQVVKMMVPLLKFYFHDNVRMAAAEAM-PFLLECARIRGSEYLSQMWQFICDPLIKAIGTEP 769

  Fly   764 QVAVVLRMLDVLYDVF-KYVPAIN-------SQEHAELIFGCIR----DIFTNKMACQFNEESGG 816
            ..       |||.::. .:..:|.       :.||.|.:.|.::    ..|.|:...|...:...
  Rat   770 DT-------DVLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEEN 827

  Fly   817 GDDE----CSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKV-----KER 872
            .|.:    ..:|.|.|..:....:::.        ..|||.|..::..::.|.|..:     ..|
  Rat   828 YDQQVEMSLQDEDECDVYILTKVSDIL--------HSLFSTYKEKILPWFEQLLPLIVNLICSSR 884

  Fly   873 DLPEQR--AYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIV-FHSE 934
            ..|:::  ..|:..:.:.|.........||   |...:...||::.:.||.:.:.||.:. |..:
  Rat   885 PWPDRQWGLCIFDDIIEHCSPTSFKYVEYF---RWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGD 946

  Fly   935 E-KSF--ESYPTILQAL--SEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPL 994
            : :|.  |:.|.:::.:  :.:..:::| .|.:|...|:.:::...|:.|.:.:|||.||:.|||
  Rat   947 DYRSLCSEAVPLLVKVIKCANSKTKKNV-IATENCISAIGKIMKFKPNCVNVDEVLPHWLSWLPL 1010

  Fly   995 KDDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESAVA- 1050
            .:|..|.        |:|:....|:   ..|: .::|.:|::|..|....:.:...:.....:|
  Rat  1011 HEDKEEAIQTLNFLCDLIESNHPVV---IGPN-NSNLPKIISIIAEGKINETISLEDPCAKRLAN 1071

  Fly  1051 LIKEIRANYPELFSKVSNMNPEVFNYVQAL 1080
            ::::|:.:........|.::.|....:|.|
  Rat  1072 VVRQIQTSEELWLECTSQLDDEQQEALQEL 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/66 (26%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	9/29 (31%)
		HEAT repeat	438..473	CDD:293787	3/34 (9%)
Ranbp6	NP_001101054.1	HEAT repeat	330..353	CDD:293787	5/22 (23%)
		HEAT repeat	363..395	CDD:293787	6/31 (19%)
		HEAT_2	371..474	CDD:290374	22/110 (20%)
		HEAT_EZ	380..434	CDD:290247	14/54 (26%)
		HEAT repeat	407..437	CDD:293787	9/36 (25%)
		HEAT repeat	449..476	CDD:293787	3/26 (12%)
		HEAT repeat	502..526	CDD:293787	3/23 (13%)
		HEAT repeat	539..572	CDD:293787	6/32 (19%)
		HEAT repeat	873..898	CDD:293787	4/24 (17%)
		HEAT repeat	910..942	CDD:293787	9/34 (26%)
		HEAT_EZ	927..987	CDD:290247	12/60 (20%)
		HEAT repeat	954..990	CDD:293787	6/36 (17%)
		HEAT repeat	999..1023	CDD:293787	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910