DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Tnpo1

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_038958071.1	Gene:	Tnpo1 / 309126	RGDID:	1308372	Length:	898	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	187/923 - (20%)
Similarity:	343/923 - (37%)	Gaps:	273/923 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILDIINGILAIDTERIRESTAKMLKAYENPD----SLLVLTQIVMSDRPVQERQVAAVLLKRRVK 65
            ||.::....:.||...|....|:.:..:.||    .:.|||::...|.|.  |.::.::||..||
  Rat    23 ILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPT--RSLSGLILKNNVK 85

  Fly    66 KLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYER 130
              .|:|..|......|||..|. .|......::.||..:| :.:..:.:.|| |.:.:.|.
  Rat    86 --AHFQNFPNGVTDFIKSECLN-NIGDSSPLIRATVGILI-TTIASKGELQN-WPDLLPKL---- 141

  Fly   131 CSSPDPIESERGSSIFSSLMDAAPD----------------------QFSNHTDTIFPLLAGILV 173
            ||..|..:.......|.:|.....|                      ||..|:.   |.:....|
  Rat   142 CSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSS---PKIRSHAV 203

  Fly   174 TAEANGNMATPT----------VHNMLAGTCVLLPFISGHSDAE--QIMVKAVPLILKALAAFAE 226
             |..|..:.:.|          :.|:.|        ::|..:||  :.:.:|:.::|:.
  Rat   204 -ACVNQFIISRTQALMLHIDSFIENLFA--------LAGDEEAEVRKNVCRALVMLLEV------ 253

  Fly   227 KGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVR--L 289
                           .|...:||:..     ::|:  |:.|.:..|.::.::...|..:|..  :
  Rat   254 ---------------RMDRLLPHMHN-----IVEY--MLQRTQDQDENVALEACEFWLTLAEQPI 296

  Fly   290 KKKIIMKQ--KLLQPTL------SVLFEVICQDDLKE---------------------------- 318
            .|.::::.  ||: |.|      |.:..::.:.|::|
  Rat   297 CKDVLVRHLPKLI-PVLVNGMKYSDIDIILLKGDVEEDEAIPDSEQDIRPRFHRSRTVAQQHEED 360

  Fly   319 ------------GDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVL 371
                        .|||..|..:|...|.||   ||::| ::..|:.:|.:|.||:..|...|.|:
  Rat   361 GIEEDDDDDDEIDDDDTISDWNLRKCSAAA---LDVLA-NVYRDELLPHILPLLKELLFHHEWVV 421

  Fly   372 RRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFL--QPTICK 434
            :.|..:.:|.|||||.:.:.....|::.::|:. :.|....||:...:.|.:::.::  ||
  Rat   422 KESGILVLGAIAEGCMQGMIPYLPELIPHLIQC-LSDKKALVRSITCWTLSRYAHWVVSQP---- 481

  Fly   435 FAPQILPVLFDYLNQLVLEL--KVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRL---- 493
              |.      .||..|:.||  ::.:.:.:..:....|..|..|....::||||..::|.|
  Rat   482 --PD------TYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAF 538

  Fly   494 --------------FG------------------VMEP--QNSNQMRE------MALSAIAAVSA 518
                          .|                  :|.|  |..|.:::      ..|..:::|:.
  Rat   539 SKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVAT 603

  Fly   519 AAKENLMPY----FPRIMTVLQGCL----VKDCPKEMYSQ-----RIQAIDTLAALCRELGKDNI 570
            |.:...:||    :.|.:.::|..|    :.:...|.|..     .|.|:|.|:.|...|| .||
  Rat   604 ALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPEQYEAPDKDFMIVALDLLSGLAEGLG-GNI 667

  Fly   571 IPLADETMNFCLMMLEDGPDD-PEFRRSIYNLMSSLSSVVNESM------------ASVFPKFID 622
            ..|...: |...:|.:...|. ||.|:|.:.|:..|:....:.:            .::.|:||.
  Rat   668 EQLVARS-NILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 731

  Fly   623 -------RIME-SVISSEDMVPNVSDNAEDDLALVDAPDI-EIDLEHTDDEDDQDAYLGENDYIV 678
                   .|.| |:....:|.|.:.......:.:::.|:. :..||:|      ...:|...|:.
  Rat   732 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENT------AITIGRLGYVC 790

  Fly   679 EKEEAILSLKEFATHTGAAFAPYL------------QSAFENVYKMID-HPQG---DVRMACIDS 727
            .:|.|.: |::|       ..|:.            .|||..:..||. :|.|   |....| |:
  Rat   791 PQEVAPM-LQQF-------IRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFC-DA 846

  Fly   728 ICSFITALHKLDD 740
            :.|:|.....|.|
  Rat   847 VASWINPKDDLRD 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/64 (30%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	6/36 (17%)
Tnpo1	XP_038958071.1	KAP95	32..767	CDD:227540	160/805 (20%)
		HEAT repeat	103..124	CDD:293787	5/22 (23%)
		HEAT repeat	137..165	CDD:293787	6/31 (19%)
		HEAT repeat	182..212	CDD:293787	7/33 (21%)
		HEAT repeat	223..249	CDD:293787	6/33 (18%)
		HEAT repeat	262..291	CDD:293787	5/35 (14%)
		HEAT repeat	407..431	CDD:293787	7/23 (30%)
		HEAT repeat	447..475	CDD:293787	5/28 (18%)
		HEAT repeat	488..518	CDD:293787	5/29 (17%)
		HEAT repeat	529..555	CDD:293787	2/25 (8%)
		HEAT repeat	570..601	CDD:293787	5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910