DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Ipo4

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001099508.1	Gene:	Ipo4 / 290228	RGDID:	1305206	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	1070	Identity:	311/1070 - (29%)
Similarity:	538/1070 - (50%)	Gaps:	86/1070 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAAILD-IINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||.|.|: |:..:|..||||||.:|.::..|..:|.:|..|..::.|....|.||.||||.:||:
  Rat     1 MEPAGLEQILKELLMPDTERIRRATEQLQTALRDPAALPALCDLLASATDPQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWRE--EILKFI 127
            .  ..|:.:..|.:.::||.:|..|....|..|..::|.:..::.|.|  ....|.:  .:|:..
  Rat    66 S--NRWRRLAPEQRESLKSLVLTALQKETEHYVSVSLAQLSATIFRKE--GLQGWPQFMNLLQHS 126

  Fly   128 YERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAG 192
            .....||   |.|.|..:.|.::.:.|:.|..|...:..||...|......| :...::..:.|.
  Rat   127 THSAHSP---EKEVGLLLLSVVVSSQPEAFHAHQQELLQLLIETLSEVSFPG-VLFYSLRTLTAL 187

  Fly   193 TCVLLPFISGHSDAEQIMVKAVPLILKALAAF--AEKGNSNEFMGAFDIIDSMAEYVPHLLTGNV 255
            ...|.|      |...:....||.::.||...  .::..:.|   |.:.:|.|.|....::|.::
  Rat   188 ARYLRP------DDVSLARMLVPKVVTALRTLIPLDEVKACE---ALEALDEMLETELPIITPHL 243

  Fly   256 KLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC-------- 312
            ..:|.|||.:|:|.....:|||::|..:..||::|.|.::|.:||.|.|:.||.::.
  Rat   244 SEVLTFCLEVAKNVALGEAIRVRILCCLTFLVKVKSKALLKNRLLPPLLNALFPIMAAEPPLGQL 308

  Fly   313 -QDDLKEGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSF 376
             .:|....|||........:|.:.|.|.:|::|||:.|:|..|.::.:||.||:|..|..|::.|
  Rat   309 DPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEAPYQRKAGF 373

  Fly   377 ICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILP 441
            :.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:::|
  Rat   374 LVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQVVRNAALFALGQFSENLQPHISSYSEEVMP 438

  Fly   442 VLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMR 506
            :|..||..:.:      .::.|:.:..||||.|.|||...:.||||.||:.:...::..:..:.:
  Rat   439 LLLTYLKSVPM------GNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTK 497

  Fly   507 EMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNII 571
            |:|:|||.|::.||:::|:||||.:|..::..|:.. ..:::..:||:::||..|.|.|| :::.
  Rat   498 ELAVSAIGAIATAAQDSLLPYFPTVMEHIREFLLTG-HDDLHLVQIQSLETLGVLARALG-ESMK 560

  Fly   572 PLADET----MNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSE 632
            |||:|.    :..|:.:     |||:.||..|:|.::||.::.||:....|:....::.|:.|:|
  Rat   561 PLAEECCQLGLGLCIHV-----DDPDVRRCTYSLFAALSGLMGESLGPYLPQITTLMLLSLRSTE 620

  Fly   633 DMVPNV-----------SDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEEAILS 686
            .:||..           ...||::..|:|.     |:|..:|:.:...|..||.:..|||:...:
  Rat   621 GIVPQYDGISSFLLFEDDSEAEEEEELMDE-----DMEEEEDDSEISGYSVENAFFDEKEDTCTA 680

  Fly   687 LKEFATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-------DDAAGL 744
            |.|.:.:|..||.|::.:.|:.|||:::.|..:||.|..:::..|..||||.       .:.|.|
  Rat   681 LGEISMNTSVAFLPFMDAIFDEVYKLLECPHMNVRKAAYEALGQFCCALHKACQRGPSDPNNAAL 745

  Fly   745 KRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGC--IRDIFTNKMA 807
            :.:...|||.:...::.:.:..||:.:|:.|..|.:...|:..|....|...|  ::.:...|.|
  Rat   746 QSSLARAIPSYMQAVKVERERPVVMAVLEALTGVLRTCGALTLQPPGRLSELCNVLKAVLQKKTA 810

  Fly   808 CQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKER 872
            ||..||.   |||..:::|.|.||.|:|....|:.........|:.:|..   |....|.|.|:.
  Rat   811 CQDAEED---DDEDDDQAEYDAMLLEHAGEAIPVLAAAAGGHAFAPFFAT---FLPLLLCKTKQS 869

  Fly   873 DLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKS 937
            ....::::..|.||:..:.|....|.:...|.|:.:..:|::|.:.|.|:.|.||.:..|....:
  Rat   870 CTVAEKSFAVGTLAESIQGLGAASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPA 934

  Fly   938 FESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVEND 1002
            .:.:|.:|..|...:.||......||||||:|||::.:|......|||...|:.||||:|..|..
  Rat   935 QDHFPKLLGLLLPLLARERHDRVRDNICGALARLLMASPAGKTEPQVLATLLHALPLKEDMEEWV 999

  Fly  1003 VIQKAFRVLYLKARPSIEAHLEQILAITIE 1032
            .|...|..|:       :.:.:|::.:..|
  Rat  1000 TIGHLFSFLH-------QNNPDQVVGVASE 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/60 (32%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
Ipo4	NP_001099508.1	KAP95	1..>620	CDD:227540	195/648 (30%)
		IBN_N	24..90	CDD:197981	21/67 (31%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT	395..425	CDD:281045	16/29 (55%)
		HEAT repeat	435..464	CDD:293787	8/34 (24%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT repeat	666..688	CDD:293787	7/21 (33%)
		HEAT repeat	698..726	CDD:293787	8/27 (30%)
		HEAT repeat	900..928	CDD:293787	9/27 (33%)
		HEAT repeat	941..971	CDD:293787	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350522
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5835
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1594
OMA	1	1.010	-	-		QHG54177
OrthoDB	1	1.010	-	-		D331433at2759
OrthoFinder	1	1.000	-	-		FOG0005113
OrthoInspector	1	1.000	-	-		otm44746
orthoMCL	1	0.900	-	-		OOG6_102877
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4732
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770