DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and kap95

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_594233.1	Gene:	kap95 / 2542496	PomBaseID:	SPAC1B1.03c	Length:	863	Species:	Schizosaccharomyces pombe

Alignment Length:	919	Identity:	184/919 - (20%)
Similarity:	349/919 - (37%)	Gaps:	216/919 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IRESTAKMLKAYENPD---SLLVLTQIVMSDRPVQE-RQVAAVLLKRRV------KKLRH---WQ 71
            :|.:..|.|:.....|   .:::|.|.:.:|..:.. |..|.:.||..:      :||.:   ||
pombe    17 VRLNAEKQLENAARTDFAQYMVLLAQELANDNSMPYIRMAAGLALKNAITAREEARKLEYQQLWQ 81

  Fly    72 LVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHE------------------EDKQNS 118
            .:|.|.:..:||..||.| ...|.....:.|.::.::..:|                  |.:.::
pombe    82 SLPVEIKQQVKSLALQTL-GSSEHQAGQSAAQLVAAIAAYELATNQWPDLMVTLVANVGEGQPSA 145

  Fly   119 WREEILKFIYERCSSPDP-IESERGSSIFSSLMDAA----PD--------------------QFS 158
            .::..|:.|...|.|..| :.|.:.::|.::::..|    ||                    .|:
pombe   146 LKQHSLQTIGYICESVSPEVLSAQSNAILTAVVAGARKEEPDAAVRLAALGALYDSLEFVRENFN 210

  Fly   159 NHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVLLPFISGHSDAEQIMVKAVPLIL-KALA 222
            |..:..:.:    .|..||.   .:|......|....|:..:..:.|       .:|..: |||.
pombe   211 NEYERNYIM----QVVCEAT---QSPEASIQTAAFGCLVKIMHLYYD-------TMPFYMEKALF 261

  Fly   223 AFAEKG--NSNEFMGAFDIIDSMAEYVPHLLTGNVKL-LLEFCLMIARNKQFDASIRVQVLTFVG 284
            |...:|  |:||                     .|.| .:||...:. .::.:.::.:|....:.
pombe   262 ALTTQGMYNTNE---------------------QVALQAVEFWSTVC-EEEIEVNLEIQEAQDLN 304

  Fly   285 SLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDDDYFSSESLNSPSNAAAQTLDLMALHMVP 349
            . |..::.....:......|.||.:::|..|....:||:       :.|.|||..|.|.| .:|.
pombe   305 E-VPARQNHGFARAAAADILPVLLKLLCNQDEDADEDDW-------NISMAAATCLQLFA-QVVG 360

  Fly   350 DKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEA----IGKKYLEVMLNIIKAGVLDSV 410
            |..:.|:|..:|..:|:|:...|.::.:..|.:.||.:.|    :..:.|.|::|:    ::|.|
pombe   361 DLIVNPVLAFVEQNIQNPDWHQREAAVMAFGSVLEGPNVAMLTPLVNQALPVLINM----MVDPV 421

  Fly   411 MFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEPDSKHM--DRMFYALET 473
            :||:....:||||.|.|:...|   .|:|      :|:.:|..|..|..|:..:  :..:..:..
pombe   422 IFVKDTTAWALGQISSFVADAI---NPEI------HLSPMVSALLQGLTDNPRIVANCCWAFMNL 477

  Fly   474 FCENLDED------IVPYLPTLMDRLFGVMEPQ-NSNQMREMALSAIAAVSAAAKENLMPYFPRI 531
            .|.....|      :.|:...::..|..|.:.: |.|..|......:..:...:.::::|....:
pombe   478 VCHFAPVDNHQTSVMTPFYEAIIGSLLHVTDQKGNENNSRTSGYETLGTLITFSSDSVLPMIANV 542

  Fly   532 MTVLQGCLVKDCPKEMYSQRIQAID-------------TLAALCRELGKDNIIPLADETMNFCLM 583
            ::::...|  :...:|.||.:...|             .|.::.|..|.| |...:|:.||..|.
pombe   543 LSIILTRL--ETSIQMQSQILDVEDRANHDELQSNLCNVLTSIIRRFGPD-IRTSSDQIMNLLLQ 604

  Fly   584 MLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSED--MVPNVSDNAEDDL 646
            .::..|........:...:.::.:.:.|......|.|:. .:.|.:|:|.  .:.:|:.....||
pombe   605 TMQTAPKQSVVHEDVLLAIGAMMNSLEEQFEVYVPSFVP-FLSSALSNEQEYQLCSVAVGLVGDL 668

  Fly   647 ALVDAPDIEIDLEHTDD------EDDQDAYLGENDYIVEKEEAILS-LKEFATHTGAAFAPYLQS 704
            |  .|.:.:| |.:.||      :|.|.:.|..|     .:.|||| ..:.|...||||..||::
pombe   669 A--RALNAKI-LPYCDDFMTRLVQDLQSSVLDRN-----VKPAILSCFSDIALAIGAAFQTYLEA 725

  Fly   705 AFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVL 769
                                       :..|        |::|..:..|..|:....|...|:.|
pombe   726 ---------------------------VMVL--------LQQASSVQAPPGANFSMIDYVDALRL 755

  Fly   770 RMLDVLYDVFKYVPAINSQEHAELIFGCIRDIFT--NKMACQFNEESGGGDDECSEESENDEM-L 831
            .:::....:   ..|:.:....:||...:..:||  |.:.         .|.||||......: |
pombe   756 GIVEAYVGI---TQAVRTDNRLDLIQPYVHSMFTLLNMIT---------ADPECSESLTRAALGL 808

  Fly   832 FENAANLFP 840
            ..:.|..||
pombe   809 LGDLAESFP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	18/73 (25%)
		HEAT repeat	356..384	CDD:293787	6/27 (22%)
		HEAT repeat	397..427	CDD:293787	11/29 (38%)
		HEAT repeat	438..473	CDD:293787	6/36 (17%)
kap95	NP_594233.1	KAP95	1..863	CDD:227540	184/919 (20%)
		IBN_N	21..101	CDD:281761	21/80 (26%)
		HEAT repeat	42..63	CDD:293787	5/20 (25%)
		HEAT repeat	75..104	CDD:293787	9/29 (31%)
		HEAT repeat	114..160	CDD:293787	5/45 (11%)
		HEAT repeat	169..204	CDD:293787	4/34 (12%)
		HEAT repeat	215..244	CDD:293787	6/35 (17%)
		HEAT repeat	323..354	CDD:293787	12/37 (32%)
		HEAT repeat	367..395	CDD:293787	6/27 (22%)
		HEAT_EZ	380..435	CDD:290247	15/58 (26%)
		HEAT repeat	408..438	CDD:293787	12/33 (36%)
		ARM	409..>480	CDD:237987	21/83 (25%)
		HEAT repeat	451..476	CDD:293787	4/24 (17%)
		HEAT repeat	496..527	CDD:293787	5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910