DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and kap123

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_596729.1	Gene:	kap123 / 2539863	PomBaseID:	SPBC14F5.03c	Length:	1067	Species:	Schizosaccharomyces pombe

Alignment Length:	1126	Identity:	269/1126 - (23%)
Similarity:	496/1126 - (44%)	Gaps:	156/1126 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAIDTERIRESTAKMLKAY-ENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRH--WQLVP 74
            :|.||.:|.|:|..:...| :.|.|||.|..|:.:....|.||:||:    ..:||.|  |..|.
pombe    17 IAPDTTQITEATRALETKYLKEPGSLLSLFHIMGTCENPQVRQLAAI----EARKLCHKYWSSVD 77

  Fly    75 AEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSSPDPIES 139
            |:.|..|:||:|.:.:...|..|:.....:|.:|.:.:. .:..|.|
pombe    78 ADVQNQIRSNLLDITLKEPESIVRHAFGRVIAALAKLDL-PEGKWNE------------------ 123

  Fly   140 ERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGT------CVLLP 198
                 :.:.|:.|..||..:..:....:|..|..|.:.:..:....| |:.:.|      .|.:.
pombe   124 -----LSAFLVQATMDQNDSIREMAVYVLYSIAETVDLDNKLLLDFV-NLFSQTITDSSRTVRVT 182

  Fly   199 FISG--------HSDAEQIM---VKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLT 252
            .:.|        .||.::::   ...:|.:|..|....:.|:.:.....||:.::.......:::
pombe   183 SVQGLGAIAEVLESDDKKLLHAYRATLPGMLLVLQDVVQVGDVDASKQVFDVFNTFLIASGAIIS 247

  Fly   253 GNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLK 317
            ..:..::|....||.:||.|..||...|:|:.|.:|.|.:.:...||.:|.:..|.||..::...
pombe   248 KALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKSRKLQALKLGKPLVLTLMEVATEETTD 312

  Fly   318 EGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVI 382
            :.|:|        .|:..|.:::||::.|:.|.:...|:.:......|||:...|:::.:.:||.
pombe   313 DIDED--------CPARLALRSIDLLSTHLSPSQVFYPMFEAACAFSQSPQASYRKAALLSIGVA 369

  Fly   383 AEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYL 447
            .||.||::... |..:..||..|:.|:.|.||.||..||.|.:..:...:.|...|:||::|:.:
pombe   370 VEGSSESVAGN-LPNIFPIIINGLCDNDMDVRQAALLALSQIAVEIPTEVSKHHAQLLPLVFELM 433

  Fly   448 NQLVLELKVGEPDSKHMDRMFYALETFCENLDE-DIVPYLPTLMDRLFGVMEPQNSNQMREMALS 511
            :  ...:|||:.....:|.:.       |.||: :|..|||.||:||.|::|..::..::....:
pombe   434 S--TQGVKVGKSACNCIDALL-------EGLDKSEISGYLPMLMERLVGLLEFSDTPDIKSCVAA 489

  Fly   512 AIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADE 576
            ||.:.:.||:::.:|||.|.|..|..||......|.|..|...:|||.|:...:||...:|..::
pombe   490 AIGSAAFAAQDDFIPYFERTMASLSQCLHTTDDDEGYELRGTVMDTLGAIANAVGKQAFLPYTEQ 554

  Fly   577 TMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSD- 640
            .:......::  .|....|...:...:.|:.|..|.    |..|::.|:.::..|.|.  :.||
pombe   555 LIQLAYEGIQ--IDHSRLRECSFCFYAVLARVYKEE----FAPFLEHIVPALFKSIDQ--DESDI 611

  Fly   641 --------NAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYI-VEKEEAILSLKEFATHTGA 696
                    .||:...|:|:  :|.:.|..|:|  .:..:|.|..| :|||.|..:|.|...:.||
pombe   612 LSERIGAPTAEEISQLLDS--VETNEEENDEE--LEKAMGVNSAIAMEKEIAADALGEICMYVGA 672

  Fly   697 AFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRT 761
            .|.|||:...|.:.....|....||.:.:.|:....|..:|:.:....:....:.:|       .
pombe   673 PFTPYLEPTVEKLVACTTHFYEGVRKSALSSLWRCATTYYKVCNVPQWQPGLPLKVP-------V 730

  Fly   762 DDQV-----AVVLRMLDVLYDVFKYVPAIN-SQEHAELIFGC----------------------- 797
            .|.|     ||.....|.|.:.::...|.: .:..||.|..|
pombe   731 PDTVKNIFEAVRKCTFDTLEEEYEKTVATDILRNFAESIKTCGPVVLGDDYEKLCEVVMEVLQKQ 795

  Fly   798 ----IRDIFTNKMACQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQ---PELFSLYF 855
                ..|:|.:    .|.||....::|. :::|.|.:|.::|.::.....:.|.   .:.|.:::
pombe   796 HIVQAGDVFDD----DFEEEDIVSNEEV-DDTEQDALLIDSACDVVIALAVALGGSFADSFKVFY 855

  Fly   856 GRLYHFYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQ 920
            .::..:|:.:..        .:||.....:.:....::.....:...:..:|:|...||:.:.|.
pombe   856 PQIVKYYMSKNG--------NERAMAVACVGEVAGGIESAITPFTRDVFSLFMAALEDSEGEVRS 912

  Fly   921 NSYFALGEIVFHSEEKSFESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVL 985
            |:.:::|.:...|.|.....|..|||.|.....:|....|:||..|.::|||:.|.:::|:.|||
pombe   913 NAAYSMGLLCQFSTEDLSSEYLNILQKLQPFFTQEVFRTALDNAIGCISRLILHNQNAIPVDQVL 977

  Fly   986 PVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSIEAHLEQILAI--TIEASYKKQMPDVETTESA 1048
            |:..:.||||:|.:||..:......||.:..|.:..||.:::.:  ::.....:|:.| |.....
pombe   978 PIVFSKLPLKEDYLENAPLYHMILALYRQQNPCLVQHLGELIPVFASVLTGSPEQLND-ELRSEL 1041

  Fly  1049 VALIKEIR-------ANYPEL 1062
            ::::|||.       :|||:|
pombe  1042 LSMVKEIAPQYESVVSNYPQL 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	23/63 (37%)
		HEAT repeat	356..384	CDD:293787	6/27 (22%)
		HEAT repeat	397..427	CDD:293787	12/29 (41%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
kap123	NP_596729.1	IBN_N	27..94	CDD:281761	24/70 (34%)
		HEAT repeat	42..67	CDD:293787	9/28 (32%)
		KAP95	54..687	CDD:227540	173/691 (25%)
		HEAT repeat	79..113	CDD:293787	9/33 (27%)
		HEAT repeat	123..153	CDD:293787	7/52 (13%)
		HEAT repeat	163..189	CDD:293787	5/26 (19%)
		HEAT repeat	340..371	CDD:293787	7/30 (23%)
		HEAT_EZ	357..410	CDD:290247	19/53 (36%)
		HEAT repeat	383..413	CDD:293787	12/29 (41%)
		HEAT repeat	424..450	CDD:293787	7/27 (26%)
		HEAT repeat	854..882	CDD:293787	3/35 (9%)
		HEAT_EZ	870..921	CDD:290247	9/50 (18%)
		HEAT repeat	894..924	CDD:293787	7/29 (24%)
		HEAT repeat	933..962	CDD:293787	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	177	1.000	Domainoid score	I836
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5835
Inparanoid	1	1.050	282	1.000	Inparanoid score	I664
OMA	1	1.010	-	-		QHG54177
OrthoFinder	1	1.000	-	-		FOG0005113
OrthoInspector	1	1.000	-	-		otm47063
orthoMCL	1	0.900	-	-		OOG6_102877
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R603
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860