DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Ranbp6

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_808389.2	Gene:	Ranbp6 / 240614	MGIID:	2683212	Length:	1105	Species:	Mus musculus

Alignment Length:	1115	Identity:	232/1115 - (20%)
Similarity:	461/1115 - (41%)	Gaps:	159/1115 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KAYENPDSLLVLTQIVMSDR----PVQERQVAAVLLKRRVKK--LRHWQLVPAEHQAAIKSNMLQ 87
            :.|||...|...|.::.:.|    ..:.||:||.||:|.:..  ...:..:|.|.|..:|   ::
Mouse    39 EVYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPPEVQRDVK---IE 100

  Fly    88 VLIAVKEKT---VKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYERCSSPDPIESERGSSIFS 147
            :::|||.:|   ::..:..|...|.|:  :|...|.|.|. |||:.:...|.:.:..|....:|.
Mouse   101 LILAVKLETHASMRKKLCDIFAVLARNLIDESGTNHWPEG-LKFLIDSIHSKNVVLWEVALHVFW 164

  Fly   148 SLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVL-----LPFISGHSDAE 207
            .......:|..:..|.|..||...:...|   :.|..|:....|.|.||     :......:|
Mouse   165 HFPGIFGNQDRHDLDIIKRLLDQCIQDQE---HPAIRTLSARAAATFVLANENNIALFKDFAD-- 224

  Fly   208 QIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFC----LMIARN 268
                 .:|.||:|:.....:.:.:......:|.|::.:|:...|...::|.|:.|    |   .|
Mouse   225 -----LLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRL---SN 281

  Fly   269 KQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDD----DYFSSESL 329
            .|...::.|.|.....:...|||...:..:.:...|:::.      ||::.||    |....:..
Mouse   282 LQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMV------DLQDDDDWVNADEMEEDDF 340

  Fly   330 NSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKY 394
            :|.:.||...||.:|..:.....:|...:.:...||||:...|.:..:.:..|.|||.:.: :..
Mouse   341 DSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKCRHAGLMALSAIGEGCHQQM-EPI 404

  Fly   395 LEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEP 459
            |:..:|.:...:.|....||.||...|||.:       ..|||.......:.:...:|.....:.
Mouse   405 LDETVNSVLLFLQDPHPRVRAAACTTLGQMA-------TDFAPSFQKKFHEIVITALLRTMENQG 462

  Fly   460 DSKHMDRMFYALETFCENLDED-IVPYLPTLMDRLFGVMEPQNSNQMR-------EMALSAIAAV 516
            :.:.......||..|.|:..:. ::.||..::..|..::..:....:|       |..::.||:|
Mouse   463 NQRVQSHAASALVIFIEDCPKSLLILYLENMVKSLHSILVIKLQELIRNGTKLALEQLVTTIASV 527

  Fly   517 SAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFC 581
            :.|.:|:.:||:...|..|:..:.....||:...|.:.|:.::.:...:||:..:..|...|...
Mouse   528 ADAIEESFIPYYDIFMPSLKHVVELAVQKELKLLRGKTIECISHVGLAVGKEKFMQDASNVMQLL 592

  Fly   582 LMM------LEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSD 640
            |..      :||  |||:     .:.|.|..:.:.:.:...|.:::..::|.:|.:.
Mouse   593 LKTQSDLNNMED--DDPQ-----TSYMVSAWARMCKILGKDFEQYLPLVIEPLIKTA-------- 642

  Fly   641 NAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEEAILSLKEFATHTGAAFAPYLQSA 705
            :|:.|:||:|..|:|   ..:||:..|...||:......|... |..|..|......:|..|:..
Mouse   643 SAKPDVALLDTQDVE---NMSDDDGWQFVNLGDQQSFGIKTSG-LEAKATACQMLVYYAKELREG 703

  Fly   706 F----ENVYKMI-----DHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRT 761
            |    |.|.||:     .:...:||:|..::: .|:....::..:..|.:..:.........:.|
Mouse   704 FVEYTEQVVKMMVPLLKFYFHDNVRVAAAEAM-PFLLECARIRGSEYLSQMWQFICDPLIKAIGT 767

  Fly   762 DDQVAVVLRMLDVLYDVF-KYVPAIN-------SQEHAELIFGCIR----DIFTNKMACQFNEES 814
            :...       |||.::. .:..:|.       :.||.|.:.|.::    ..|.|:...|...:.
Mouse   768 EPDT-------DVLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQE 825

  Fly   815 GGGDDE----CSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKV-----K 870
            ...|.:    ..:|.|.|..:....:::.        ..|||.|..::..::.|.|..:     .
Mouse   826 ENYDQQVEMSLQDEDECDVYILTKVSDIL--------HSLFSTYKEKILPWFEQLLPLIVNLICS 882

  Fly   871 ERDLPEQR--AYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIV-FH 932
            .|..|:::  ..|:..:.:.|.........||   |...:...||::.:.||.:.:.||.:. |.
Mouse   883 SRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYF---RWPMLLNMRDNNPEVRQAAAYGLGVMAQFG 944

  Fly   933 SEE-KSF--ESYPTILQAL--SEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHL 992
            .:: :|.  |:.|.:::.:  :.:..:::| .|.:|...|:.:::...|:.|.:.:|||.||:.|
Mouse   945 GDDYRSLCSEAVPLLVKVIKCANSKTKKNV-IATENCISAIGKILKFKPNCVNVDEVLPHWLSWL 1008

  Fly   993 PLKDDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESAV 1049
            ||.:|..|.        |:|:....|:   ..|: .::|.:|::|..|....:.:...:.....:
Mouse  1009 PLHEDKEEAIQTLNFLCDLIESNHPVV---IGPN-NSNLPKIISIIAEGKINETISHEDPCAKRL 1069

  Fly  1050 A-LIKEIRAN 1058
            | ::::|:.:
Mouse  1070 ANVVRQIQTS 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/66 (26%)
		HEAT repeat	356..384	CDD:293787	6/27 (22%)
		HEAT repeat	397..427	CDD:293787	9/29 (31%)
		HEAT repeat	438..473	CDD:293787	3/34 (9%)
Ranbp6	NP_808389.2	HEAT repeat	185..207	CDD:293787	5/24 (21%)
		HEAT 1	219..257		7/44 (16%)
		HEAT repeat	225..253	CDD:293787	5/27 (19%)
		HEAT repeat	265..297	CDD:293787	8/34 (24%)
		HEAT repeat	330..353	CDD:293787	5/22 (23%)
		HEAT 2	361..399		10/37 (27%)
		HEAT repeat	363..395	CDD:293787	7/31 (23%)
		HEAT_2	371..474	CDD:290374	23/110 (21%)
		HEAT_EZ	380..434	CDD:290247	14/54 (26%)
		HEAT 3	402..440		11/44 (25%)
		HEAT repeat	407..437	CDD:293787	9/36 (25%)
		HEAT 4	444..483		5/38 (13%)
		HEAT repeat	449..476	CDD:293787	3/26 (12%)
		HEAT repeat	502..526	CDD:293787	3/23 (13%)
		HEAT repeat	539..572	CDD:293787	6/32 (19%)
		HEAT 5	866..905		6/38 (16%)
		HEAT repeat	873..898	CDD:293787	4/24 (17%)
		HEAT 6	908..946		10/40 (25%)
		HEAT repeat	910..942	CDD:293787	9/34 (26%)
		HEAT_EZ	927..987	CDD:290247	12/60 (20%)
		HEAT 7	949..987		7/38 (18%)
		HEAT repeat	954..990	CDD:293787	6/36 (17%)
		HEAT repeat	999..1023	CDD:293787	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810