DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Tnpo2

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001116315.1	Gene:	Tnpo2 / 212999	MGIID:	2384849	Length:	897	Species:	Mus musculus

Alignment Length:	852	Identity:	169/852 - (19%)
Similarity:	308/852 - (36%)	Gaps:	272/852 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TERIRESTAKMLKAYENPD----SLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRHWQLVPAEH 77
            |:||.:...|.|..:  ||    .:.|||::...|.|.  |.::.::||..||  .|:|..|...
Mouse    27 TQRIVQDKLKQLNQF--PDFNNYLIFVLTRLKSEDEPT--RSLSGLILKNNVK--AHYQSFPPPV 85

  Fly    78 QAAIK----------SNMLQVLIAVKEKTV--KG----------------------TVAFIIGSL 108
            ...||          |::::..|.:...|:  ||                      |.....|:|
Mouse    86 ADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGAL 150

  Fly   109 VRHEEDKQNSWREEIL---------KFI--YERCSSPDPIESERGSSIFSSLMDAAP------DQ 156
            .:..||.......:.|         ||:  ::.||  ..|.|...:.:...:||.|.      |.
Mouse   151 QKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCS--PKIRSHAIACVNQFIMDRAQALMDNIDT 213

  Fly   157 FSNHTDTIFPLLA------------GILVTAEANGNMATPTVHNMLAGTCVLLPFISGHSDAEQI 209
            |..|   :|.|..            .:::..|...:...|.:|:::.   .:|.....|.  |.:
Mouse   214 FIEH---LFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQ---YMLQRTQDHD--ENV 270

  Fly   210 MVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDA- 273
            .::|....|    ..||:....|.:.:     .:.:.:|.|:.|.....::..|:....::.:|
Mouse   271 ALEACEFWL----TLAEQPICKEVLAS-----HLVQLIPILVNGMKYSEIDIILLKGDVEEDEAV 326

  Fly   274 -----SIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDDDYFSSESLNSPS 333
                 .|:.:        ....:.:.:..:..:|..|       :|...:.|||..|..:|...|
Mouse   327 PDSEQDIKPR--------FHKSRTVTLTHEAERPDSS-------EDAEDDDDDDALSDWNLRKCS 376

  Fly   334 NAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVM 398
            .||   ||::| ::..::.:|.||.||:..|..||.|::.|..:.:|.|||||.:.:.....|::
Mouse   377 AAA---LDVLA-NVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELI 437

  Fly   399 LNIIKAGVLDSVMFVRTAAFFALGQFSEFL--QPTICKFAPQILPVLFDYLNQLVLEL--KVGEP 459
            .::|:. :.|....||:.|.:.|.:::.::  ||      |.:      :|..|:.||  ::.:.
Mouse   438 PHLIQC-LSDKKALVRSIACWTLSRYAHWVVSQP------PDM------HLKPLMTELLKRILDG 489

  Fly   460 DSKHMDRMFYALETFCENLDEDIVPYLPTLMDRL---FG-------------------------- 495
            :.:..:....|..|..|....::||||..::|.|   ||
Mouse   490 NKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLN 554

  Fly   496 -------VMEP--QNSNQMRE------MALSAIAAVSAAAKENLMPY----FPRIMTVLQGCLVK 541
                   :|.|  |..|::::      ..|..:::|:.|.:...:||    :.|.:|::|..|.:
Mouse   555 QPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQ 619

  Fly   542 DCPKEMYSQR------------IQAIDTLAALCRELG--------KDNIIPLADETMNFCLMMLE 586
               ..||:|.            |.|:|.|:.|...||        :.||:.|..:.|...:
Mouse   620 ---AMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSM---- 677

  Fly   587 DGPDDPEFRRSIYNLMSSLSSV----VNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLA 647
                 ||.|:|.:.|:..|:..    |...:|...|
Mouse   678 -----PEVRQSSFALLGDLTKACFIHVKPCIAEFMP----------------------------- 708

  Fly   648 LVDAPDIEIDLEHTDDEDDQDAYLGEN---DYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENV 709
                                  .||.|   ::|.....|..::.|.....||...||:|....|:
Mouse   709 ----------------------ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNL 751

  Fly   710 YKMIDHP 716
            .::|:.|
Mouse   752 VEIINRP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	18/74 (24%)
		HEAT repeat	356..384	CDD:293787	11/27 (41%)
		HEAT repeat	397..427	CDD:293787	6/29 (21%)
		HEAT repeat	438..473	CDD:293787	5/36 (14%)
Tnpo2	NP_001116315.1	HEAT 1. /evidence=ECO:0000250\|UniProtKB:Q92973	9..36		3/8 (38%)
		KAP95	22..756	CDD:227540	167/848 (20%)
		HEAT 2. /evidence=ECO:0000250\|UniProtKB:Q92973	41..79		13/43 (30%)
		HEAT 3. /evidence=ECO:0000250\|UniProtKB:Q92973	88..121		7/32 (22%)
		HEAT repeat	93..114	CDD:293787	2/20 (10%)
		HEAT 4. /evidence=ECO:0000250\|UniProtKB:Q92973	127..164		5/36 (14%)
		HEAT repeat	127..155	CDD:293787	3/27 (11%)
		HEAT repeat	165..202	CDD:293787	7/38 (18%)
		HEAT 5. /evidence=ECO:0000250\|UniProtKB:Q92973	171..201		6/31 (19%)
		HEAT repeat	213..239	CDD:293787	4/28 (14%)
		HEAT 6. /evidence=ECO:0000250\|UniProtKB:Q92973	214..241		4/29 (14%)
		HEAT repeat	252..281	CDD:293787	6/37 (16%)
		HEAT 7. /evidence=ECO:0000250\|UniProtKB:Q92973	253..280		6/35 (17%)
		HEAT 8. /evidence=ECO:0000250\|UniProtKB:Q92973	296..386		20/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..363		3/25 (12%)
		HEAT 9. /evidence=ECO:0000250\|UniProtKB:Q92973	394..422		10/27 (37%)
		HEAT 10. /evidence=ECO:0000250\|UniProtKB:Q92973	434..461		7/27 (26%)
		HEAT repeat	436..464	CDD:293787	6/28 (21%)
		HEAT 11. /evidence=ECO:0000250\|UniProtKB:Q92973	475..508		7/32 (22%)
		HEAT repeat	477..507	CDD:293787	5/29 (17%)
		HEAT 12. /evidence=ECO:0000250\|UniProtKB:Q92973	516..549		5/32 (16%)
		HEAT repeat	518..544	CDD:293787	4/25 (16%)
		HEAT 13. /evidence=ECO:0000250\|UniProtKB:Q92973	557..595		7/37 (19%)
		HEAT repeat	559..590	CDD:293787	5/30 (17%)
		HEAT 14. /evidence=ECO:0000250\|UniProtKB:Q92973	603..654		13/53 (25%)
		HEAT repeat	664..696	CDD:293787	10/40 (25%)
		HEAT 15. /evidence=ECO:0000250\|UniProtKB:Q92973	665..696		9/39 (23%)
		HEAT 16. /evidence=ECO:0000250\|UniProtKB:Q92973	704..737		8/83 (10%)
		HEAT repeat	705..731	CDD:293787	6/76 (8%)
		HEAT 18. /evidence=ECO:0000250\|UniProtKB:Q92973	798..831
		HEAT 19. /evidence=ECO:0000250\|UniProtKB:Q92973	840..871
		HEAT 20. /evidence=ECO:0000250\|UniProtKB:Q92973	874..894
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910