DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and AgaP_AGAP006942

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_308814.4	Gene:	AgaP_AGAP006942 / 1270142	VectorBaseID:	AGAP006942	Length:	1097	Species:	Anopheles gambiae

Alignment Length:	1096	Identity:	463/1096 - (42%)
Similarity:	725/1096 - (66%)	Gaps:	30/1096 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 INGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRHWQLV 73
            |..:|..|.:.|:::||::.:|::.|:::..|.:|.:::...|.||.||:|||:.:.|||.|:.|
Mosquito     5 IKNLLVADNDLIQQATAELKEAFKKPETIPQLCEICVTNTDPQVRQYAAMLLKKHLGKLRAWREV 69

  Fly    74 PAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSSPDPIE 138
            |||.||.||..||:.::...||:|:..:...:|.||:||.:|::.|..|:|||::|..||.||..
Mosquito    70 PAETQALIKKGMLEAIVNESEKSVRNAITGFVGVLVKHEAEKEDGWMGEVLKFMFESTSSSDPKL 134

  Fly   139 SERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVLLPFISGH 203
            ||.|||:|::|.|.|||||..|.:.:..|.:..|...||:||||||.::|:|.|...|:|||.|.
Mosquito   135 SELGSSVFNTLTDVAPDQFMPHIEMVCQLFSTALTATEASGNMATPVIYNILLGMSHLVPFIPGR 199

  Fly   204 SDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFCLMIARN 268
            .:.||....::|.:||||:||||: :|.:|:.||||::::|:.....|:.::|||::|||.:|.|
Mosquito   200 QEIEQTYQDSIPYVLKALSAFAEQ-DSYKFIEAFDILENLADESSRTLSPHMKLLIDFCLQMAGN 263

  Fly   269 KQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVI-CQDDLKEGDDDYFSSESLNSP 332
            .|.|.|:||:.:||:|.|||||||:|:||||::|.::.||.:: ...|:::.|::||.|..:::|
Mosquito   264 TQLDDSVRVKTITFIGWLVRLKKKMIIKQKLVEPIVNALFTLMSVAPDVEDEDEEYFGSNEVSTP 328

  Fly   333 SNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEV 397
            |..|.|:||::|||:.|.:..|||:.||||||....|:.::::::.:.||||||||.|..|||.|
Mosquito   329 STCATQSLDVLALHIPPKQLFPPLMALLEPALAGDNPLPKKAAYLSIAVIAEGCSEHICSKYLRV 393

  Fly   398 MLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEPDSK 462
            ::::||.|:.|..:.:|.||.||||||||.|||.|.:.|.:|||:||::|.||.|:::.|..:..
Mosquito   394 LVDVIKRGITDENVMIRNAALFALGQFSEHLQPEISQHADEILPILFEFLQQLCLQIRSGGKEPP 458

  Fly   463 HMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMREMALSAIAAVSAAAKENLMPY 527
            |:||:||||||.||||::.:.||||.||:|||..::.:||..:||::|:.|||.::||||:::||
Mosquito   459 HIDRVFYALETTCENLEDQVTPYLPMLMERLFESLDTRNSVHLRELSLTTIAATASAAKEHMLPY 523

  Fly   528 FPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDGPDDP 592
            |||::..|:..|||...:::.:.|.|||||.|||.|.:||||.:|||.:|:|..|.|:::. :||
Mosquito   524 FPRLIDCLKLYLVKTDDEDICTLRPQAIDTFAALVRTIGKDNFLPLAVDTLNMGLTMMDES-NDP 587

  Fly   593 EFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALV-------- 649
            :.|||.|||.:|::|.|.|.|:....|.::.::|||.|||.:||...:.|.||:|::
Mosquito   588 DLRRSCYNLFASMASSVKEDMSGSLNKIVETMLESVRSSEGIVPTFKEGAGDDMAILANGALAGT 652

  Fly   650 ------DAPDIEIDLEHT--DDEDDQDAYLG---ENDYIVEKEEAILSLKEFATHTGAAFAPYLQ 703
                  |..|.|.|:|::  |:|:|::...|   ||.|:.|||||||:|.|||.|||.||||::|
Mosquito   653 NGSGDGDDEDEEFDIENSVGDEEEDEEDIAGYSIENAYMDEKEEAILALMEFAEHTGPAFAPFIQ 717

  Fly   704 SAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVV 768
            :|||.:||:::||..|:|.|.||::..|:.|||:|.:..|:.:...|.:||.:.|:|||::..||
Mosquito   718 TAFEEIYKLLNHPNEDIRKASIDAVKQFVVALHQLGNMEGVHQTILILVPKLSEIIRTDEERTVV 782

  Fly   769 LRMLDVLYDVFKYVPAINSQE--HAELIFGCIRDIFTNKMACQFNEESGGGDDECSEESENDEML 831
            :..||...|:.:.|.|...|.  ..:.:|.||.|:...|:||||:|..    ||..||||.||.:
Mosquito   783 MSALDGFSDILQEVGAATFQADGQKDAVFNCIVDVLNGKVACQFDEPV----DEEQEESEYDEAI 843

  Fly   832 FENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERD--LPEQRAYIYGALADCCKALKG 894
            .|:|.::.|.||..|..|.|::||||::.::||::.|.|::|  ...|||:..|.||:|.:.||.
Mosquito   844 LESAGDILPKFGRALPAEEFAVYFGRVWPYFIQKIEKTKQKDETSDSQRAFAIGVLAECFEGLKE 908

  Fly   895 CCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPTILQALSEAIVRESVPA 959
            ....:.|.|.|||::..:|.:.:.|.|:.:.|||:|.|.::.:|..||.|:.|||:.:.:|....
Mosquito   909 FNRNWIDTLLPIFLSCVQDRNNEVRSNTVYGLGEMVKHGKDCTFGHYPQIMAALSQLVSKEQHAG 973

  Fly   960 AMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSIEAHLE 1024
            .:||:|||:||||:||...|||..||||::.:|||::|..||..:.:...:||.:...::...|.
Mosquito   974 TLDNLCGALARLIITNCSLVPLKSVLPVFVEYLPLREDFTENLAVFQCLDLLYKQGDENLIPALC 1038

  Fly  1025 QILAITIEASYKKQMPDVETTESAVALIKEIRANYPELFSKVSNMNPEVFNYVQAL 1080
            :||.:.::...||:....|..|....|:|:|..::|:.|::|...:.|...:||.|
Mosquito  1039 RILVVGLQVLCKKEYDTEECRELVHNLVKQISKDFPDKFAEVIRSSAEAAEFVQTL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	26/60 (43%)
		HEAT repeat	356..384	CDD:293787	10/27 (37%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	17/34 (50%)
AgaP_AGAP006942	XP_308814.4	IBN_N	19..87	CDD:197981	28/67 (42%)
		HEAT repeat	249..288	CDD:293787	22/38 (58%)
		HEAT repeat	352..380	CDD:293787	10/27 (37%)
		HEAT repeat	393..423	CDD:293787	15/29 (52%)
		HEAT repeat	434..469	CDD:293787	17/34 (50%)
		HEAT_EZ	694..745	CDD:290247	30/50 (60%)
		HEAT repeat	718..755	CDD:293787	17/36 (47%)
		HEAT repeat	764..791	CDD:293787	11/26 (42%)
		HEAT repeat	874..901	CDD:293787	10/26 (38%)
		HEAT repeat	916..946	CDD:293787	11/29 (38%)
		HEAT	917..946	CDD:281045	11/28 (39%)
		HEAT repeat	957..984	CDD:293787	10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	717	1.000	Domainoid score	I416
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5835
Inparanoid	1	1.050	896	1.000	Inparanoid score	I1150
OMA	1	1.010	-	-		QHG54177
OrthoDB	1	1.010	-	-		D331433at2759
OrthoFinder	1	1.000	-	-		FOG0005113
OrthoInspector	1	1.000	-	-		otm49825
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4732
TreeFam	1	0.960	-	-
	13	12.940