DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18823 and NCOA5

DIOPT Version :9

Sequence 1:	NP_659571.1	Gene:	CG18823 / 59184	FlyBaseID:	FBgn0042146	Length:	106	Species:	Drosophila melanogaster
Sequence 2:	NP_066018.1	Gene:	NCOA5 / 57727	HGNCID:	15909	Length:	579	Species:	Homo sapiens

Alignment Length:	92	Identity:	21/92 - (22%)
Similarity:	35/92 - (38%)	Gaps:	28/92 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VRNLPPCTRQELVMLCLPFGKILGSLIVDN--------EGFIQFARESE---ATSAIDALDQIVF 71
            ||...|...|.|:           :|:.||        :..|.:.||.:   ..|:.|:|...:.
Human   334 VRGGHPPAIQSLI-----------NLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPIS 387

  Fly    72 KSKVLQVSNATF------PPIEGGQVL 92
            :..:...|.|:.      .|::.||||
Human   388 RQPLGATSGASLKTQPSSQPLQSGQVL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18823	NP_659571.1	RRM	<9..>79	CDD:223796	14/71 (20%)
CG18823	NP_659571.1	RRM_1	16..76	CDD:278504	14/68 (21%)
NCOA5	NP_066018.1	Transcription repression	1..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		PRK12678	<32..>135	CDD:237171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..173
		HisS	<186..256	CDD:223202
		LXXLL motif	345..349		1/14 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..428		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..537
		Transcription activation	458..579
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421126at33208
OrthoFinder	1	1.000	-	-		FOG0006056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010