Protein Alignment Tsp42Ea and CD63

DIOPT Version :10

• Sequence 1: NP_525012.2
• Gene: Tsp42Ea / 59178
• FlyBaseID: FBgn0029508
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_001771.1
• Gene: CD63 / 967
• HGNCID: 1692
• Length: 238
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 73/240 - (30%)
• Similarity: 123/240 - (51%)
• Gaps: 36/240 - (15%)

  Fly     4 GISMVKYILFIFNLLCSIC----GILLIVFGALLFSKVRNMDDFAEALRTQQVPVTMIILGTIIL 64
            |:..||::|::  ||.:.|    |::.:..||.|   |.:......|.....:||.:|.:|..:.
Human     6 GMKCVKFLLYV--LLLAFCACAVGLIAVGVGAQL---VLSQTIIQGATPGSLLPVVIIAVGVFLF 65

  Fly    65 LISWFGCCGAIRESYCMSMTYSILLFVLMIGQLALVIYMWVQKDKYLEIMGDVVEKAWNHRTSRS 129
            |:::.|||||.:|:||:.:|::|.|.::|:.::|..|..:|.:||.:....:      |.|....
Human    66 LVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNN------NFRQQME 124

  Fly   130 DY---------MDAIQISMKCCGRSGYTDY-----AYQGKFPPSCCSDTN-----NCRWETVYRR 175
            :|         :|.:|...||||.:.|||:     ..:.:.|.|||.:..     |...:.:::.
Human   125 NYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKE 189

  Fly   176 GCKVTFVEFWDR-NSDIIKYAGLVIAAIEFVGFVFACCLANSIRN 219
            || |..:..|.| |..::..|.|.||.:|.:|.||||||..|||:
Human   190 GC-VEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRS 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ea	NP_525012.2	Tetraspanin	8..215	CDD:459767	69/230 (30%)
CD63	NP_001771.1	Tetraspanin	10..229	CDD:459767	69/230 (30%)
		CD63_LEL	105..203	CDD:239419	25/104 (24%)
		Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731	234..238		73/240 (30%)