Protein Alignment Tsp42Ea and TSPAN18

DIOPT Version :10

• Sequence 1: NP_525012.2
• Gene: Tsp42Ea / 59178
• FlyBaseID: FBgn0029508
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: XP_005253274.1
• Gene: TSPAN18 / 90139
• HGNCID: 20660
• Length: 258
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 54/259 - (20%)
• Similarity: 105/259 - (40%)
• Gaps: 61/259 - (23%)

  Fly     5 ISMVKYILFIFNLLCSICGILLIVFGALLFSKVRNMDD---FAEALRTQQVPVT----MIILGTI 62
            :|.:||::|:||....:.|..|:..|..:      |.|   |.|.:....:.:|    ::.:|.:
Human    16 LSCMKYLMFVFNFFIFLGGACLLAIGIWV------MVDPTGFREIVAANPLLLTGAYILLAMGGL 74

  Fly    63 ILLISWFGCCGAIRESYCMSMTYSILLFVLMIGQLALVIYMWV----------QKDKYLEIMG-- 115
            :.|:.:.|||||:||:.|:.:.:.:.:.::.:.:|:..|..::          .|:......|
Human    75 LFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRENLTREFFTKELTKHYQGNN 139

  Fly   116 --DVVEKAWNHRTSRSDYMDAIQISMKCCGRSGYTDYAYQGKF----------PPSCCS------ 162
              ||....||          ::.|:..|||.:|..|:.:...|          |.:||.
Human   140 DTDVFSATWN----------SVMITFGCCGVNGPEDFKFASVFRLLTLDSEEVPEACCRREPQSR 194

  Fly   163 -----DTNNC---RWETVYRRGCKVTFVEFWDRNSDIIKYAGLVIAAIEFVGFVFACCLANSIR 218
                 ....|   |...:.::||....:..::....:.....:.:.|||....:||.||...|:
Human   195 DGVLLSREECLLGRSLFLNKQGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFAMCLFRGIQ 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ea	NP_525012.2	Tetraspanin	8..215	CDD:459767	52/251 (21%)
TSPAN18	XP_005253274.1	Tetraspanin	20..255	CDD:459767	52/250 (21%)
		uroplakin_I_like_LEL	115..228	CDD:239409	20/122 (16%)