Protein Alignment Tsp42Ea and TSPAN14

DIOPT Version :10

• Sequence 1: NP_525012.2
• Gene: Tsp42Ea / 59178
• FlyBaseID: FBgn0029508
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 59/257 - (22%)
• Similarity: 115/257 - (44%)
• Gaps: 46/257 - (17%)

  Fly     1 MSCGISMVKYILFIFNLLCSICGILLIVFGALLFSKVRNMDDFAEALRTQQV-PVTMIIL-GTII 63
            :||   ..||:||.:|::..:.|::.:..|...:|:...:.|..:..|...: ||.:::: |.::
Human    11 VSC---WYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVM 72

  Fly    64 LLISWFGCCGAIRESYCMSMTYS---ILLFV--LMIGQLALVIYMWVQKDKYLEIMGDVVEKAWN 123
            ..:.:.||.||:||:.|:...:.   :|:|.  |.:..||.:...|| :|::.|.....: |::.
Human    73 FTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWV-RDRFREFFESNI-KSYR 135

  Fly   124 HRTSRSDYMDAIQISMKCCGRSGYTDYAYQGKF--------------PPSCCSD-------TNNC 167
            ......:.:|::|.:.:|||..|..|:.....|              |.|||..       ...|
Human   136 DDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQC 200

  Fly   168 ----------RW-ETVYRRGCKVTFVEFW-DRNSDIIKYAGLVIAAIEFVGFVFACCLANSI 217
                      :| |:::.:|| :..:|.| .||..|:....:.|:.::..|...|..|.:.|
Human   201 GYDVRIQLKSKWDESIFTKGC-IQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDI 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ea	NP_525012.2	Tetraspanin	8..215	CDD:459767	56/246 (23%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	55/244 (23%)
		TM4SF9_like_LEL	113..233	CDD:239412	25/122 (20%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		24/120 (20%)