Protein Alignment Tsp42Ea and tsp-17

DIOPT Version :10

• Sequence 1: NP_525012.2
• Gene: Tsp42Ea / 59178
• FlyBaseID: FBgn0029508
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_001129920.2
• Gene: tsp-17 / 192067
• WormBaseID: WBGene00006643
• Length: 312
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 138/737 - (18%)
• Similarity: 232/737 - (31%)
• Gaps: 234/737 - (31%)

  Fly    49 SAVDASKKTTSATGWQSVGLFVPDGSGRQAAKVIDTPPVAPPRKKRGATLDGRYRSDEALKVKNG 113
            |.|...|....|:|   :.|||...:            .:|..|::..    |..|.|....||.
 Worm    70 SLVSIYKNMEDASG---IKLFVSQNN------------PSPSDKEKQV----RDASVEKASDKNR 115

  Fly   114 FQDVFGRESRRHSCDISSVTRPASVPPPRPDDVAALPARQTSCFEIDASNDAFSDFSKVPTTAEL 178
            .....||.|:|:.   ...|:...|..|.|  :...|:.||.              .:|.....|
 Worm   116 QGSRKGRASKRNE---YGKTKEIDVDAPGP--IVMKPSSQTK--------------KRVQLLQNL 161

  Fly   179 ERTPSTSQIPRVGNRKSDKFFGE----RLADSLSLEQEGQQGAEVRKQPRREKSSASSLVRDDVD 239
            .....|.....|...:..|.:.|    ||.:..||.:||             ..|....:||: |
 Worm   162 SAESLTKPTESVETAEKPKDYTENTVIRLDEHPSLNKEG-------------NLSPFFWLRDE-D 212

  Fly   240 KIEKFVESTETSAEVKQKPEKKPTASDEPAAAPEKPEGEEDLMKYIDRTVAKDNQIGRRAEFLMA 304
            ..|...:.||:...:...|...|:.||...:..|.|..|::..        |.|.
 Worm   213 DGENSSQRTESDQLLGTTPVNVPSFSDLMDSDHESPSKEDEQQ--------KPNP---------- 259

  Fly   305 MLEDYNDSVRYEGMEPVEEPLIVPKRRKSKHICDD------------------------------ 339
              .|..||..:|..:....|.|:|...|:|.:..|
 Worm   260 --GDMFDSEMFEWTQRPCSPEILPSPVKAKVLGRDEIDLTQKKLPKVKVASSKCKNRKAGSARNT 322

  Fly   340 ----------HDHMHDKLHA---HERDA-SASG-VVRTEVSIEQAPRKPSRDFSRYKPIDAAEPH 389
                      .|:|.....|   .::|: ..|| ::|.:|:.::..:......|:.:........
 Worm   323 VARRSIGVSQEDNMESSAAATISEQQDSRGTSGTIIRNDVNTDENVKAKRATRSKAQSTRVQSDL 387

  Fly   390 GSSDGSDGEQGSVVRPARTKQKQRESAARAAPPQTPPPPAPPRFQKSHSETQFTNAASSSTQLAQ 454
            ..|:.:||:||:         |::.|:.:::|..   |.|.|            |..|..|::..
 Worm   388 NVSNEADGKQGT---------KRKRSSIKSSPAH---PIAGP------------NELSLGTEIVG 428

  Fly   455 PAQDDDEPKAHTPRMLKRIISMPATEHLDKVPSRPDTPQRPTLTK--SSSSGSFSVVDLQRTLIS 517
            ..   |:.:||.|.              |..|.:....::|:|.|  ..|:.|.|:.||..   .
 Worm   429 KG---DQDQAHGPS--------------DTHPEKRSPTEKPSLKKRGRKSNASSSLKDLSG---K 473

  Fly   518 VERFTPEDFVHRAGADELVKPKSKLTTRKISWKSNEPPTPVATDGPAGASFTIGG---------- 572
            .::.|.|             .|.||.:..||.|:.:|    ..:|...|....||
 Worm   474 TQKKTSE-------------KKLKLDSHMISSKATQP----HGNGILTAGLNQGGDKQDSRNNRK 521

  Fly   573 TTVVTTSAPPEVPARHRSDASRTEPEPAAPAKSAPTSAASFLVDDVQDSSLRQFCLGSFLESSRV 637
            :||            .:.|.:....|..:....:.:..::.|          :.|.||..:.
 Worm   522 STV------------GKDDHTMQVIEKCSTINKSSSGGSAHL----------RRCNGSLTKK--- 561

  Fly   638 LPHHDVVNVLDCVY-SATDNKENILEQFQTFLEEALTAELNAPNPTNPNVRKLREKLSQ-AQEAA 700
                     ..|.: ..:::.|...|....:..|.::|:.|.    ...|..:.:..:: |....
 Worm   562 ---------FTCAFCQCSEDTEASGEMTHYYRGEPVSADFNG----GSKVIHVHKNCAEWAPNVY 613

  Fly   701 DGDSQLENESIKLAGSSRTSCS 722
            ..|..:.|..::|..|.|.|||
 Worm   614 FNDLTIVNLDVELTRSRRISCS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ea	NP_525012.2	Tetraspanin	8..215	CDD:459767	38/169 (22%)
tsp-17	NP_001129920.2	Tetraspanin	11..>150	CDD:459767	24/103 (23%)
		CD37_CD82_like_LEL	153..275	CDD:239413	32/155 (21%)