Protein Alignment Tsp42Ea and Cd63

DIOPT Version :10

• Sequence 1: NP_525012.2
• Gene: Tsp42Ea / 59178
• FlyBaseID: FBgn0029508
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_031679.1
• Gene: Cd63 / 12512
• MGIID: 99529
• Length: 238
• Species: Mus musculus
• Alignment Length: 240
• Identity: 67/240 - (27%)
• Similarity: 124/240 - (51%)
• Gaps: 36/240 - (15%)

  Fly     4 GISMVKYILFIFNLLCSICGILLIVFGA---LLFSKVRNMDDFAEALRTQQVPVTMIILGTIILL 65
            |:..||::|::..|....|.:.||..|.   ::..:....:..|.:|    :||.:|.:|..:.|
Mouse     6 GMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSL----LPVVIIAVGAFLFL 66

  Fly    66 ISWFGCCGAIRESYCMSMTYSILLFVLMIGQLALVIYMWVQKDKYLEIMGDVVEKAWN--HRTSR 128
            :::.|||||.:|:||:.:|::|.|.::|:.::|:.|..:|.:|:        |:..:|  .:...
Mouse    67 VAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQ--------VKSEFNKSFQQQM 123

  Fly   129 SDY---------MDAIQISMKCCGRSGYTDY-----AYQGKFPPSCCSDT-----NNCRWETVYR 174
            .:|         :|.:|....|||.|.|||:     ..:.:.|.|||.:.     |:.:..|::.
Mouse   124 QNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTIHT 188

  Fly   175 RGCKVTFVEFWDRNSDIIKYAGLVIAAIEFVGFVFACCLANSIRN 219
            :||..|...:..:|..::..|.|.||.:|.:|.:|:|||..|||:
Mouse   189 QGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRS 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ea	NP_525012.2	Tetraspanin	8..215	CDD:459767	63/230 (27%)
Cd63	NP_031679.1	Tetraspanin	10..229	CDD:459767	63/230 (27%)
		CD63_LEL	105..203	CDD:239419	23/105 (22%)
		Lysosomal targeting motif. /evidence=ECO:0000269|PubMed:21041449	234..238		67/240 (28%)