Protein Alignment Tsp42Eb and PRPH2

DIOPT Version :10

• Sequence 1: NP_724525.1
• Gene: Tsp42Eb / 59177
• FlyBaseID: FBgn0042086
• Length: 222
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 52/268 - (19%)
• Similarity: 101/268 - (37%)
• Gaps: 75/268 - (27%)

  Fly    12 LYLLNLVFVAGGILLIVVGSIMLSTMGNFTAFDGGVNTQTIPICIIVIGSVTFVVAFFGCCGTIR 76
            |:|:|...|..||::..:|..:...:...:.......:..:|..:|.:|.::.|  |....|.|.
Human    20 LWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSLIGMGVLSCV--FNSLAGKIC 82

  Fly    77 ENACCTTIYA---------ICMLILFGLQLAL-SIWIFAANDKFLSSMGKAVDKAW----DENNA 127
            .:|.....||         :.:.:||.:.|.| ::..|.......:::|:.:....    |.:..
Human    83 YDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTP 147

  Fly   128 AQGY---PMDALQLAFSCCGNTGYQQY--------------------------------ETVPSS 157
            .:.:   .:|.||:.|.||||.|::.:                                :.||.|
Human   148 GRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFS 212

  Fly   158 CC--------------------GYKDRTKVCEAEIYSQRPGCRQEFVDFWASNTDLIRWSSLIIA 202
            ||                    .|..:|:  |..::.:  |||...:.:::|..:.:...:|:|.
Human   213 CCNPSSPRPCIQYQITNNSAHYSYDHQTE--ELNLWVR--GCRAALLSYYSSLMNSMGVVTLLIW 273

  Fly   203 LFELGIFI 210
            |||:.|.|
Human   274 LFEVTITI 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eb	NP_724525.1	Tetraspanin	8..216	CDD:459767	52/268 (19%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	33/162 (20%)
		peripherin_like_LEL	120..262	CDD:239415	24/145 (17%)
		Interaction with MREG. /evidence=ECO:0000250	341..346