Protein Alignment Tsp42Eb and Tspan14

DIOPT Version :10

• Sequence 1: NP_724525.1
• Gene: Tsp42Eb / 59177
• FlyBaseID: FBgn0042086
• Length: 222
• Species: Drosophila melanogaster
• Sequence 2: NP_666040.1
• Gene: Tspan14 / 52588
• MGIID: 1196325
• Length: 270
• Species: Mus musculus
• Alignment Length: 255
• Identity: 64/255 - (25%)
• Similarity: 110/255 - (43%)
• Gaps: 60/255 - (23%)

  Fly     4 LSAMFKYLLYLLNLVFVAGGILLIVVG------SIMLSTMGNFTAFDGGVNTQTIP-ICIIVIGS 61
            :|..:||||:..|:||...|::.:.||      ..:||.:...|...|     ..| :.::::|.
Mouse    11 VSCWYKYLLFSYNIVFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRLHG-----IDPVVLVLMVGV 70

  Fly    62 VTFVVAFFGCCGTIRENACCTTIYAICMLILFGLQLALSIWIFAAND-------KFLSSMGKAVD 119
            |.|.:.|.||.|.:|||.|....:...::::|.|:||:::..|...|       :|..|..|:..
Mouse    71 VMFTLGFAGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYR 135

  Fly   120 KAWDENNAAQGYPMDALQLAFSCCGNTGYQQYET-----------------VPSSC--------- 158
            ...|..|.     :|:||.|..|||..|.:.::.                 ||.||
Mouse   136 DDIDLQNL-----IDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKV 195

  Fly   159 ----CGYKDRTKV---CEAEIYSQRPGCRQEFVDFWASNTDLIRWSSLIIALFEL-GIFI 210
                |||..|.::   .:..|:::  ||.|....:...|..::....:.|:|.:: |||:
Mouse   196 VNTQCGYDVRIQLKSKWDEFIFTK--GCIQALEGWLPRNIYIVAGVFIAISLLQIFGIFL 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eb	NP_724525.1	Tetraspanin	8..216	CDD:459767	63/251 (25%)
Tspan14	NP_666040.1	Tetraspanin	16..258	CDD:459767	63/250 (25%)
		TM4SF9_like_LEL	113..233	CDD:239412	27/126 (21%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000250|UniProtKB:Q8NG11	114..232		26/124 (21%)