DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18815 and LYPLA1

DIOPT Version :9

Sequence 1:	NP_001261719.1	Gene:	CG18815 / 59176	FlyBaseID:	FBgn0042138	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_006321.1	Gene:	LYPLA1 / 10434	HGNCID:	6737	Length:	230	Species:	Homo sapiens

Alignment Length:	214	Identity:	117/214 - (54%)
Similarity:	143/214 - (66%)	Gaps:	4/214 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PVIVEATVKQTATLIFMHGLGDTGHGWSSALAAIRPPFMKVICPTAPTQPVSLNAGFRMPSWFDL 68
            |.||.|..|.||.:||:||||||||||:.|.|.||...:|.|||.||.:||:||....||||||:
Human    11 PAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDI 75

  Fly    69 KTLDIGGPEDEPGIQSARDSVHGMIQKEISAGIPANRIVLGGFSQGGALALYSALTYDQPLAGVV 133
            ..|.....|||.||:.|.:::..:|.:|:..|||:|||:||||||||||:||:|||..|.||||.
Human    76 IGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVT 140

  Fly   134 ALSCWLPLHKQFPGAKVN--SDDVPIFQAHGDYDPVVPYKFGQLSASLLKSFMK--NVTFKTYSG 194
            ||||||||...||...:.  :.|:.|.|.|||.||:||..||.|:...||:.:.  |||||||.|
Human   141 ALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEG 205

  Fly   195 LSHSSSDDEMDDVKDIISK 213
            :.|||...||.|||..|.|
Human   206 MMHSSCQQEMMDVKQFIDK 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18815	NP_001261719.1	Abhydrolase_2	4..214	CDD:280406	117/214 (55%)
LYPLA1	NP_006321.1	Abhydrolase_2	11..226	CDD:396693	117/214 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156567
Domainoid	1	1.000	235	1.000	Domainoid score	I2372
eggNOG	1	0.900	-	-		E1_COG0400
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3404
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S960
OMA	1	1.010	-	-		QHG53978
OrthoDB	1	1.010	-	-		D1373549at2759
OrthoFinder	1	1.000	-	-		FOG0000652
OrthoInspector	1	1.000	-	-		otm42120
orthoMCL	1	0.900	-	-		OOG6_100696
Panther	1	1.100	-	-	LDO	PTHR10655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R75
SonicParanoid	1	1.000	-	-		X443
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790