DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18814 and hpgd

DIOPT Version :9

Sequence 1:	NP_652673.2	Gene:	CG18814 / 59175	FlyBaseID:	FBgn0042137	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001313470.1	Gene:	hpgd / 565975	ZFINID:	ZDB-GENE-080728-2	Length:	261	Species:	Danio rerio

Alignment Length:	253	Identity:	77/253 - (30%)
Similarity:	134/253 - (52%)	Gaps:	8/253 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLEGKNVVYLGGFGGIGKKCVQELLKKQIKGLAIFDL--IVDDDLLAEWKKQHPDTEIFYQKMD 63
            |.|.||..:..||..|||:..|:|||:...| :|:.||  .|.::..::...|..:....:.:.|
Zfish     1 MSLHGKTALVTGGAQGIGRAVVEELLQNGAK-VALVDLNQSVGEECKSDLDDQFGEDNCIFIQCD 64

  Fly    64 ITQKSDIDAAYKATAEKLGHFDVVVNGSGLLDDRRIELTIQINLVGVINSTLTALEYMDKSKGGR 128
            :|....:..|::.|.::.|..|:|:|.:|:.:::..|.||::||..||..|..|||:|.|..|.:
Zfish    65 VTDGEKLGDAFRNTVDRFGRLDIVINNAGINNEKNWEKTIEVNLTSVIKGTYLALEHMSKEYGKQ 129

  Fly   129 GGLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTRAMASPIHYAHSGVGFITICPGYTNTGILKDI 193
            ||.|:|:||:|....:|...:|:.:|.||..|:||||......:.||....:||.:.:|.:|:.:
Zfish   130 GGAIINVSSMAAFLHSPHQPVYTATKYGVIGFSRAMADASEQGNYGVRINALCPAFVDTQLLQTV 194

  Fly   194 DKKTT---FPFYETRMRTVFSKVKGQTAEVCARNIVNAI-ETAKNGAVLMLELGE-IH 246
            :.:.|   |..|:...:....|.......:.|..::..| :.:.||||:.:...: ||
Zfish   195 EHEETMGKFVKYKDDFKQRMDKYGVLKPSLIAEGMLRLITDESLNGAVMKITCSKGIH 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18814	NP_652673.2	NADB_Rossmann	6..248	CDD:304358	74/248 (30%)
CG18814	NP_652673.2	adh_short	6..196	CDD:278532	62/191 (32%)
hpgd	NP_001313470.1	ADH_SDR_c_like	6..254	CDD:187584	74/248 (30%)
hpgd	NP_001313470.1	adh_short	6..198	CDD:278532	62/192 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585839
Domainoid	1	1.000	134	1.000	Domainoid score	I4954
eggNOG	1	0.900	-	-		E2759_KOG4169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4534
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6395
orthoMCL	1	0.900	-	-		OOG6_100916
Panther	1	1.100	-	-	LDO	PTHR44229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760