DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18814 and Pdh

DIOPT Version :9

Sequence 1:	NP_652673.2	Gene:	CG18814 / 59175	FlyBaseID:	FBgn0042137	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_524105.2	Gene:	Pdh / 39812	FlyBaseID:	FBgn0011693	Length:	278	Species:	Drosophila melanogaster

Alignment Length:	257	Identity:	98/257 - (38%)
Similarity:	151/257 - (58%)	Gaps:	6/257 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLEGKNVVYLGGFGGIGKKCVQELLKKQIKGLAIFDLIVDDDLLAEWKK---QHPDTEIFYQKM 62
            |...|||.|..||.||||.:..::||......:||.||   .|.|.|:.|   .||...:...||
  Fly    18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDL---QDNLEEFVKLRAAHPTQSVMIIKM 79

  Fly    63 DITQKSDIDAAYKATAEKLGHFDVVVNGSGLLDDRRIELTIQINLVGVINSTLTALEYMDKSKGG 127
            |:..|..::|.|:..|:..|:.|:|||.:|:.:|:.::.|:.:||.|:|||||:||.||.|..||
  Fly    80 DVANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYMGKDNGG 144

  Fly   128 RGGLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTRAMASPIHYAHSGVGFITICPGYTNTGILKD 192
            :||::||:|||.||.|..::.:|..:|.|:..|||.:|:..:|..||:.|:|:|||.|.|.:..:
  Fly   145 KGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVTVCPGATMTDMFTN 209

  Fly   193 IDKKTTFPFYETRMRTVFSKVKGQTAEVCARNIVNAIETAKNGAVLMLELGEIHELDIPNLW 254
            ..:|..||........:..::..|:|...:|.|:|.:|..|||||.::|...::.|:|...|
  Fly   210 FTEKIIFPETSDETYRILDRLNKQSAADVSRCILNVLEKDKNGAVYVIEGKRVYPLEIKPQW 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18814	NP_652673.2	NADB_Rossmann	6..248	CDD:304358	93/244 (38%)
CG18814	NP_652673.2	adh_short	6..196	CDD:278532	78/192 (41%)
Pdh	NP_524105.2	NADB_Rossmann	23..259	CDD:304358	92/238 (39%)
Pdh	NP_524105.2	adh_short	23..214	CDD:278532	78/193 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455196
Domainoid	1	1.000	96	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG4169
Homologene	1	1.000	-	-		H134459
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4534
Isobase	1	0.950	-	0.861353	Normalized mean entropy	S2756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053465at2759
OrthoFinder	1	1.000	-	-		FOG0008550
OrthoInspector	1	1.000	-	-		mtm6395
orthoMCL	1	0.900	-	-		OOG6_100916
Panther	1	1.100	-	-	P	PTHR44229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2961
	13	12.750