Protein Alignment CG18814 and HSD17B10

DIOPT Version :10

• Sequence 1: NP_652673.2
• Gene: CG18814 / 59175
• FlyBaseID: FBgn0042137
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_004484.1
• Gene: HSD17B10 / 3028
• HGNCID: 4800
• Length: 261
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 67/266 - (25%)
• Similarity: 109/266 - (40%)
• Gaps: 46/266 - (17%)

  Fly     3 LEGKNVVYLGGFGGIGKKCVQELLKKQIKGLAIFDLIVDDDLLAEWKKQHPDTEIFYQKMDITQK 67
            ::|...|..||..|:|....:.|: .|.....:.||   .:...|.:.:.......:...|:|.:
Human     8 VKGLVAVITGGASGLGLATAERLV-GQGASAVLLDL---PNSGGEAQAKKLGNNCVFAPADVTSE 68

  Fly    68 SDIDAAYKATAEKLGHFDVVVNGSGL----------------LDDRRIELTIQINLVGVINSTLT 116
            .|:..|......|.|..||.||.:|:                |:|  .:..:.:||:|..|....
Human    69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTFNVIRL 131

  Fly   117 ALEYM---DKSKGGRGGLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTRAMASPIHYAHSGVGFI 178
            ....|   :..:||:.|:|:|.:|||..:.....|.||.||.|:...|..:|..:  |..|:..:
Human   132 VAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL--APIGIRVM 194

  Fly   179 TICPGYTNTGILKDIDKK------TTFPFYETRMRTVFSKVKGQTAEVCARNIVNAI--ETAKNG 235
            ||.||...|.:|..:.:|      :..|| .:|:        |..||..  ::|.||  ....||
Human   195 TIAPGLFGTPLLTSLPEKVCNFLASQVPF-PSRL--------GDPAEYA--HLVQAIIENPFLNG 248

  Fly   236 AVLMLE 241
            .|:.|:
Human   249 EVIRLD 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18814	NP_652673.2	Rossmann-fold NAD(P)(+)-binding proteins	6..248	CDD:473865	66/263 (25%)
HSD17B10	NP_004484.1	HSD10-like_SDR_c	9..261	CDD:187629	67/265 (25%)