DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdap2 and parp14rs1

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001107919.2	Gene:	parp14rs1 / 791754	ZFINID:	ZDB-GENE-070424-157	Length:	1810	Species:	Danio rerio

Alignment Length:	468	Identity:	92/468 - (19%)
Similarity:	170/468 - (36%)	Gaps:	112/468 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PRHNRSPFPLCKDVNNRFVIWDGDMTTLEVDAITNTSDETLTESNSISERIFAVAGNQLREELST 116
            ||..:|.:...........:...||.:.:|||:.....|||.....:::.:...||.:|:::...
Zfish   761 PRKVKSVYQFKTREGMEITVHKADMCSFQVDAVVGACKETLLLDGGLAKALSDAAGPKLQKDCDK 825

  Fly   117 TVK--ECRTGD-VRITRGYNLPAKYVLHTVAPAYREKFKTAAENTLHCCYRNVLCKAKELNLHTI 178
            .||  :..||| |.:..|..|..|:|:..:.|.|.......:|..|....:..|..|.:.:..:|
Zfish   826 LVKGRKFTTGDAVLLDAGGRLHCKHVILAIGPHYNSSKPQESEKLLKKAVKRSLNVADQESFQSI 890

  Fly   179 ALCNISAHQKSFPADVAAHIALRTIRRYLDKCTLQVVILCVGSSERGTYEVLA------PLYFPR 237
            |:..||:....||.|:.|...::.|:.:.|.....:.:..:...:.....|.|      .:|...
Zfish   891 AIPAISSGVFGFPMDLCAFTIVKAIKEFCDFVEGDIALTKIHLVDNNDKTVQALEAAVKKVYGVS 955

  Fly   238 DQLEERSALWQLPKDIGGEFGEPQHPDPDRQIRIIRNP-QHSVH--------------------- 280
            ||....|:                 ....:|.:...:| ||.:.
Zfish   956 DQSTTGSS-----------------SSSQQQNKASASPSQHQLTTFFQGASQTESFQTKEGLTIT 1003

  Fly   281 -MRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYSSGLQAQLQRDLDRQHLLSDRPRTG 344
             |:.::.|...||..:.:   ||||:...    |...|:.......|||..||:|       .||
Zfish  1004 LMKGNIEDTTMDVVVNTL---SSDLKLNV----GAVSNALFKAAGPQLQDLLDQQ-------ATG 1054

  Fly   345 -------------------VYENVISEGVEGIEHQERYERLLRRAQVEDLTEVSGIGCLYQSGVD 390
                               |:..|:....:|..::::.        :|::.:.    ||.::  :
Zfish  1055 PASSGAVFETAGANLKNKLVFHAVVPHWNQGQGNEQKV--------LENVMDT----CLCKA--E 1105

  Fly   391 RLGRPVIVFCGKWFPAQNIDLEKALLYLIKLLDPIVKGDYVISYFHTLTSTNNYPSLHWLREVYS 455
            :..:..|||..  ....|:...|:|: :..:||.:.|       |.|..|:.:      ::||..
Zfish  1106 QRQQSSIVFSA--IGTGNLGFPKSLV-VSTMLDSVFK-------FSTKRSSKH------IQEVAF 1154

  Fly   456 VLPYKYKKNLKAF 468
            ||..|..:.::.|
Zfish  1155 VLHPKDTQTIQVF 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	39/175 (22%)
		Macro_GDAP2_like	67..207	CDD:239233	36/142 (25%)
		CRAL_TRIO_2	393..518	CDD:290435	18/76 (24%)
parp14rs1	NP_001107919.2	RRM1_PAR14	7..86	CDD:240746
		RRM	129..>295	CDD:223796
		RRM2_PAR14	211..282	CDD:240987
		YmdB	775..953	CDD:225021	39/177 (22%)
		Macro	775..951	CDD:294024	39/175 (22%)
		YmdB	999..1161	CDD:225021	41/205 (20%)
		Macro	1000..1140	CDD:294024	33/177 (19%)
		YmdB	1209..1368	CDD:225021
		Macro	1211..1336	CDD:294024
		WWE	1546..1608	CDD:295449
		PARP	1635..1809	CDD:279038
		TCCD_inducible_PARP_like	1691..1809	CDD:238719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810