DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdap2 and gdap2

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001015874.1	Gene:	gdap2 / 548591	XenbaseID:	XB-GENE-996028	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	514	Identity:	201/514 - (39%)
Similarity:	303/514 - (58%)	Gaps:	41/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SCPVKLDNLATWGGSQKTDTRLPITDYSNLGGPRHN-RSPFPLCKDVNNRFVIWDGDMTTLEVDA 83
            ||.|..|.|..|...:..:.. .:.|......|... .||||...|:|.:.::|.||:..|...|
Frog     8 SCFVDADALPCWADVRDGEGE-DVPDGGRKDAPHGGLHSPFPYRNDINKKVILWRGDVALLSCTA 71

  Fly    84 ITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVRITRGYNLPAKYVLHTVAPAYR 148
            :.|||:||||:.|.:|:.||..:|.:|.||:. .:|.||||:.::|:|:||.|:|::|||.|.|:
Frog    72 LVNTSNETLTDKNPVSDSIFRYSGPELSEEMQ-KLKGCRTGEAKLTKGFNLAARYIIHTVGPKYK 135

  Fly   149 EKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPADVAAHIALRTIRRYLDK--CT 211
            .|::||||::|:.||||||..|||..:.::..|.|:..::.:|.:.:.||||||:||:|:.  ..
Frog   136 TKYRTAAESSLYSCYRNVLQLAKEQGMASVGFCVIATQKRCYPPEDSTHIALRTVRRFLEAHGAA 200

  Fly   212 LQVVILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGGEFGEPQHPDPDRQIRIIRNPQ 276
            |:.|:..|...|.|||..|.||||||...||:.::..||:|||...|||  ..|:|||||...|.
Frog   201 LEKVVFAVTEQEEGTYRRLLPLYFPRSLEEEQRSIPFLPQDIGNAEGEP--VVPERQIRISEKPG 263

  Fly   277 HSVHMRHHLADDDSDVSPHDMEGNSSDLEYG-ARDMNGLSLNSYSSGLQAQLQRDLDRQHLLSDR 340
            ..        ||||:             |.| .:|::.:..:::     |:::.|:|:|..|:
Frog   264 GQ--------DDDSE-------------EEGLVKDLSVIGSHAF-----ARMEGDVDKQRRLA-- 300

  Fly   341 PRTGVYENVISEGVEGIEHQERYERLLRRAQVEDLTEVSGIGCLYQSGVDRLGRPVIVFCGKWFP 405
                 .:..:|......:||..|.|.|.||:.|||::::.:..|||||||..||.|:|..|:..|
Frog   301 -----LQGQLSGAAMQKQHQRNYNRWLSRARTEDLSDIAALKALYQSGVDNCGRTVMVVVGRNIP 360

  Fly   406 AQNIDLEKALLYLIKLLDPIVKGDYVISYFHTLTSTNNYPSLHWLREVYSVLPYKYKKNLKAFYI 470
            ...||:||||||.|.::|.:...:||:.||||||..:|:|...:|:.:|.::..||||||||.|.
Frog   361 VLLIDMEKALLYFIHMMDHVAAKEYVLVYFHTLTGEHNHPDSDFLKNMYDIVDVKYKKNLKALYF 425

  Fly   471 VHPTFWTKMMTWWFTTFMAPAIKAKVHSLPGVEHLYSAITKDQLEIPAYITEYDMATNG 529
            |||||.:|:.:|:||||....:|.|||.:..:..|:||:..:|:|||.::.:||...||
Frog   426 VHPTFRSKVSSWFFTTFTVSGLKDKVHQVESLHQLFSAVPPEQIEIPPFVLDYDARENG 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	72/168 (43%)
		Macro_GDAP2_like	67..207	CDD:239233	62/139 (45%)
		CRAL_TRIO_2	393..518	CDD:290435	58/124 (47%)
gdap2	NP_001015874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..45		2/23 (9%)
		Macro_GDAP2-like	56..223	CDD:394876	72/167 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..271		11/39 (28%)
		CRAL_TRIO_2	348..479	CDD:404584	59/130 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4779
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7728
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2056
OMA	1	1.010	-	-		QHG55405
OrthoDB	1	1.010	-	-		D564346at33208
OrthoFinder	1	1.000	-	-		FOG0007360
OrthoInspector	1	1.000	-	-		oto102842
Panther	1	1.100	-	-	LDO	PTHR11106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4847
SonicParanoid	1	1.000	-	-		X5478
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110