DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdap2 and GDAP2

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_060156.1	Gene:	GDAP2 / 54834	HGNCID:	18010	Length:	497	Species:	Homo sapiens

Alignment Length:	524	Identity:	209/524 - (39%)
Similarity:	312/524 - (59%)	Gaps:	48/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VKLDNLATWGGS-----QKTDTRLPITDYSNLGGPRHNRSPFPLCKDVNNRFVIWDGDMTTLEVD 82
            |.:|.|.:||.|     ..:||...|.....:      ||||...||||.:.|:|.||:..|...
Human    11 VDVDTLPSWGDSCQDELNSSDTTAEIFQEDTV------RSPFLYNKDVNGKVVLWKGDVALLNCT 69

  Fly    83 AITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVRITRGYNLPAKYVLHTVAPAY 147
            ||.|||:|:||:.|.:||.||.:||..|:|:|. .:|.||||:.::|:|:||.|::::|||.|.|
Human    70 AIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQ-KLKGCRTGEAKLTKGFNLAARFIIHTVGPKY 133

  Fly   148 REKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPADVAAHIALRTIRRYLD--KC 210
            :.:::||||::|:.||||||..|||.::.::..|.|::.::.:|.:.|.||||||:||:|:  ..
Human   134 KSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGE 198

  Fly   211 TLQVVILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGGEFGEPQHPDPDRQIRIIRNP 275
            |::.|:..|...|.|||:.|.||||||...||..:|..||.|||...|||  ..|:|||||...|
Human   199 TIEKVVFAVSDLEEGTYQKLLPLYFPRSLKEENRSLPYLPADIGNAEGEP--VVPERQIRISEKP 261

  Fly   276 QHSVHMRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYSSGLQAQLQRDLDRQHLLSDR 340
            .                :|.|   |..:.:.|.    |:.|:...|...|:::.|:|:|..|
Human   262 G----------------APED---NQEEEDEGL----GVDLSFIGSHAFARMEGDIDKQRKL--- 300

  Fly   341 PRTGVYENVISEGVEGIEHQERYERLLRRAQVEDLTEVSGIGCLYQSGVDRLGRPVIVFCGKWFP 405
                :.:..:||.....:||..|.|.|.:|:.|||::::.:..|||:|||..||.|:|..|:..|
Human   301 ----ILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIP 361

  Fly   406 AQNIDLEKALLYLIKLLDPIVKGDYVISYFHTLTSTNNYPSLHWLREVYSVLPYKYKKNLKAFYI 470
            ...||::|||||.|.::|.|...:||:.|||||||..|:....:|:::|.|:..|||:||||.|.
Human   362 VTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYF 426

  Fly   471 VHPTFWTKMMTWWFTTFMAPAIKAKVHSLPGVEHLYSAITKDQLEIPAYITEYDMATNGLHY--F 533
            |||||.:|:.||:||||....:|.|:|.:..:..|:|||:.:|::.|.::.|||...||.:|  :
Human   427 VHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSY 491

  Fly   534 NPVP 537
            .|.|
Human   492 PPSP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	74/168 (44%)
		Macro_GDAP2_like	67..207	CDD:239233	64/139 (46%)
		CRAL_TRIO_2	393..518	CDD:290435	57/124 (46%)
GDAP2	NP_060156.1	Macro_GDAP2_like	54..193	CDD:239233	64/139 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..273		9/39 (23%)
		CRAL_TRIO_2	349..480	CDD:372686	59/130 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158363
Domainoid	1	1.000	134	1.000	Domainoid score	I5038
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7728
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2086
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55405
OrthoDB	1	1.010	-	-		D564346at33208
OrthoFinder	1	1.000	-	-		FOG0007360
OrthoInspector	1	1.000	-	-		oto88975
orthoMCL	1	0.900	-	-		OOG6_105245
Panther	1	1.100	-	-	LDO	PTHR11106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4847
SonicParanoid	1	1.000	-	-		X5478
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800