DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdap2 and Parp14

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_006522455.1	Gene:	Parp14 / 547253	MGIID:	1919489	Length:	1846	Species:	Mus musculus

Alignment Length:	508	Identity:	94/508 - (18%)
Similarity:	171/508 - (33%)	Gaps:	163/508 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RFVIWDGDMTTLEVDAITNTSDETLTESNSISERIFAVAGNQLREELSTTVKE---CRTGDVRIT 129
            :..:.:.|::...||.:.|.::|.|...:.:::.:...||.:|:.|....|||   ...|:..|:
Mouse   814 KLFVLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAVIS 878

  Fly   130 RGYNLPAKYVLHTVAPAYREKFKTAAENTLHC------CYRNVLCKAKELNLHTIALCNISAHQK 188
            :...||..:|:|.|.|.::      .:..|.|      ..|..|..|:|....:||:..:||...
Mouse   879 KAGKLPCHHVIHAVGPRWK------GDKVLECVSLLKKVVRQSLSLAEEHRCRSIAMPAVSAGIF 937

  Fly   189 SFPADVAAHIALRTIRRYL----DKCTLQVVILCVG----------SSERGTY-EVLAPLYFPRD 238
            .||.::.....:..|:.:.    |..||:.:.| ||          .:.:.|| :.|:...|| .
Mouse   938 DFPLELCVANIVSAIKEHFQHKRDTHTLKKIYL-VGLPAKVARAFAEAVKTTYKDSLSHTAFP-S 1000

  Fly   239 QLEERSALWQLPKDIGGEFGEPQHPDPDRQIRIIRNPQHSVHMRHHLADDDSDVSPHDMEGNSSD 303
            .|:....|.:.|:..|.....|:    ..:||::.....:. ..|.:.   :.:|| |::.|...
Mouse  1001 SLKALVPLGKTPQKQGSLLVSPE----GLRIRLVEEGVQNA-TTHAIV---NSISP-DLKLNKGP 1056

  Fly   304 LEYGARDMNGLSLNSYSSGLQAQLQRDLDRQHLLSDRPRTGVYENVISEGVEGIEHQERYERLLR 368
            |.....:..|           .:||.:|.|.                .:||.
Mouse  1057 LSQAFLEKAG-----------PKLQEELTRS----------------GQGVS------------- 1081

  Fly   369 RAQVEDLTEVSGIGCLYQSGVDRLGRPVIVFCGKWFPAQNIDLEKALLYLIKLLDPIVKGDYVIS 433
                   .:|..|  |..||.:...|.|.......:.:.|      ..:.:|::..|::
Mouse  1082 -------VDVGTI--LQTSGCNLNSRHVFHVVPPPWKSNN------SAWSLKIMKNIIR------ 1125

  Fly   434 YFHTLTSTNN-----------------YPSLHWLREVYS-VLPYKYKKNLKAF----YIVHPTFW 476
              ..|.:|.|                 :|...:.:.:.| ||.:..:..||..    :::||
Mouse  1126 --DCLKTTENLSLQSIAFPAIGTGNLRFPKPEFAKLIISEVLKFSSRNQLKTLQEVQFLLHP--- 1185

  Fly   477 TKMMTWWFTTFMAPAIKAKVHSLPGVEHLYSAITKDQLEIPAYITEYDMATNG 529
                                              ||...|.|:..|:|...||
Mouse  1186 ----------------------------------KDHENIQAFSDEFDKRNNG 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	43/189 (23%)
		Macro_GDAP2_like	67..207	CDD:239233	34/147 (23%)
		CRAL_TRIO_2	393..518	CDD:290435	19/146 (13%)
Parp14	XP_006522455.1	RRM1_PAR14	6..87	CDD:240746
		RRM2_PAR14	226..300	CDD:240987
		Macro	812..986	CDD:381759	40/178 (22%)
		A1pp	1026..1160	CDD:214701	29/201 (14%)
		A1pp	1240..1358	CDD:214701
		TCCD_inducible_PARP_like	1724..1844	CDD:238719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810