DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdap2 and gdap2

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001004563.1	Gene:	gdap2 / 447824	ZFINID:	ZDB-GENE-040912-31	Length:	504	Species:	Danio rerio

Alignment Length:	522	Identity:	202/522 - (38%)
Similarity:	308/522 - (59%)	Gaps:	47/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VKLDNLATWGGSQKTDTRLPITDY---------SNLGGPRHN-RSPFPLCKDVNNRFVIWDGDMT 77
            |::.||.||...|.....|...::         .||....:: .|||...:|:||:.|:::||:.
Zfish    11 VEVLNLPTWDQPQGVQDELDGENHYEEEEEEEEDNLTNQLNSVNSPFTFRQDINNKIVLFNGDVA 75

  Fly    78 TLEVDAITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVRITRGYNLPAKYVLHT 142
            .|...||.|||:||||:.|.||:.|...||.:||:|| ..:|.||||:.::|.|::|.|::::||
Zfish    76 LLNCTAIVNTSNETLTDKNPISDSIHRHAGPELRDEL-LKLKGCRTGEAKMTEGFDLAARFIIHT 139

  Fly   143 VAPAYREKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPADVAAHIALRTIRRYL 207
            |.|.|:.|::||||::|:.||||||..|||..:.::..|.||..::::|.:.|.||||||:||:|
Zfish   140 VGPKYKAKYRTAAESSLYSCYRNVLQLAKEHAMVSVGFCVISTVKRAYPVEDATHIALRTVRRFL 204

  Fly   208 DKC--TLQVVILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGGEFGEPQHPDPDRQIR 270
            :..  .::.::..|...|...|..|.|||:||.:.|||.:|..||.|||...|||  ..|:||||
Zfish   205 ENHGENIETLVFAVSDVEEPVYRKLLPLYYPRSKQEERISLPLLPADIGNSEGEP--VVPERQIR 267

  Fly   271 IIRNPQHSVHMRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYSSGLQAQLQRDLDRQH 335
            |...|.       :|.||..|      :...|||        ||    ..|...|:::.|:|:|.
Zfish   268 IAEKPV-------NLEDDPED------DSLDSDL--------GL----VGSHAFARMEGDVDKQR 307

  Fly   336 LLSDRPRTGVYENVISEGVEGIEHQERYERLLRRAQVEDLTEVSGIGCLYQSGVDRLGRPVIVFC 400
            .|       :.:..:||..:..:||..|.|.|.:|:.|||::::.:..|||:|||..||.|:|..
Zfish   308 KL-------ILQGQMSEVAQQKQHQRNYNRWLCKARAEDLSDIAALKALYQTGVDLCGRTVMVVV 365

  Fly   401 GKWFPAQNIDLEKALLYLIKLLDPIVKGDYVISYFHTLTSTNNYPSLHWLREVYSVLPYKYKKNL 465
            |:..|...||:||||||.|.::|.|...:||:.||||||..:|:....:|:::|.::..|:||||
Zfish   366 GRNIPVMLIDMEKALLYFIHVMDHITVKEYVMVYFHTLTGEHNHLDTDFLKKLYDIVDAKFKKNL 430

  Fly   466 KAFYIVHPTFWTKMMTWWFTTFMAPAIKAKVHSLPGVEHLYSAITKDQLEIPAYITEYDMATNGL 530
            :|||.|||||.:|:.||:||||....:|.|||.:..::.|::.:..:|::||.::.|||...|..
Zfish   431 RAFYFVHPTFRSKVSTWFFTTFSVSGLKDKVHHIENLQQLFTCVLPEQIDIPPFVLEYDSRVNSP 495

  Fly   531 HY 532
            :|
Zfish   496 YY 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	72/168 (43%)
		Macro_GDAP2_like	67..207	CDD:239233	66/139 (47%)
		CRAL_TRIO_2	393..518	CDD:290435	55/124 (44%)
gdap2	NP_001004563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..46		2/25 (8%)
		YmdB	65..230	CDD:225021	70/165 (42%)
		Macro_GDAP2_like	65..204	CDD:239233	66/139 (47%)
		CRAL_TRIO_2	358..481	CDD:290435	54/122 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594287
Domainoid	1	1.000	135	1.000	Domainoid score	I4947
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7728
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2178
OMA	1	1.010	-	-		QHG55405
OrthoDB	1	1.010	-	-		D564346at33208
OrthoFinder	1	1.000	-	-		FOG0007360
OrthoInspector	1	1.000	-	-		oto40451
orthoMCL	1	0.900	-	-		OOG6_105245
Panther	1	1.100	-	-	LDO	PTHR11106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4847
SonicParanoid	1	1.000	-	-		X5478
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800