DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdap2 and Gdap2

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_034399.1	Gene:	Gdap2 / 14547	MGIID:	1338001	Length:	498	Species:	Mus musculus

Alignment Length:	523	Identity:	204/523 - (39%)
Similarity:	315/523 - (60%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VKLDNLATWGGSQKTDTRLPITDYSNLGGPRH----NRSPFPLCKDVNNRFVIWDGDMTTLEVDA 83
            |.:|.|.:||.|.:.:     .|.::......    :||||...:|||.:.|:|.||:..|...|
Mouse    11 VDVDTLLSWGDSYEDE-----VDCADSTAEAFQEDASRSPFVYSRDVNGKVVLWKGDVALLNCTA 70

  Fly    84 ITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVRITRGYNLPAKYVLHTVAPAYR 148
            |.|||:|:||:.|.:||.||.:||..|:|:|. .:|.||||:.::|:|:||.|::::|||.|.|:
Mouse    71 IVNTSNESLTDKNPVSESIFMLAGPDLKEDLQ-KLKGCRTGEAKLTKGFNLAARFIIHTVGPKYK 134

  Fly   149 EKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPADVAAHIALRTIRRYLD--KCT 211
            .:::||||::|:.||||||..|||.::.::..|.|::.::.:|.:.|.||||||:||:|:  ...
Mouse   135 SRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGEN 199

  Fly   212 LQVVILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGGEFGEPQHPDPDRQIRIIRNPQ 276
            ::.|:..|...|..||:.|.||||||...||..:|..||.|||...|||  ..|:|||||...|.
Mouse   200 IEKVVFAVSELEEATYQKLLPLYFPRSLKEEIRSLPYLPADIGNAEGEP--VVPERQIRISEKPG 262

  Fly   277 HSVHMRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYSSGLQAQLQRDLDRQHLLSDRP 341
                     |.:|::....| ||...||.:         :.|::.   |:::.|:|:|..|
Mouse   263 ---------ASEDNEEEDED-EGLGVDLSF---------IGSHAF---ARMEGDIDKQRKL---- 301

  Fly   342 RTGVYENVISEGVEGIEHQERYERLLRRAQVEDLTEVSGIGCLYQSGVDRLGRPVIVFCGKWFPA 406
               :.:..:||.....:||..|.|.|.:|:.|||::::.:..|||:|||..||.|:|..|:..|.
Mouse   302 ---ILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPV 363

  Fly   407 QNIDLEKALLYLIKLLDPIVKGDYVISYFHTLTSTNNYPSLHWLREVYSVLPYKYKKNLKAFYIV 471
            ..||::|||||.|.::|.|...:||:.|||||||..|:....:|:::|.|:..|||:||||.|.|
Mouse   364 TLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSDYNHLDSDFLKKLYDVVDIKYKRNLKAVYFV 428

  Fly   472 HPTFWTKMMTWWFTTFMAPAIKAKVHSLPGVEHLYSAITKDQLEIPAYITEYDMATNGLHY--FN 534
            ||||.:|:.||:||||....:|.|:|.:..::.|:|||:.:|::.|.::.|||...||.::  :.
Mouse   429 HPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLQQLFSAISPEQIDFPPFVLEYDARENGPYFASYP 493

  Fly   535 PVP 537
            |.|
Mouse   494 PSP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	72/168 (43%)
		Macro_GDAP2_like	67..207	CDD:239233	64/139 (46%)
		CRAL_TRIO_2	393..518	CDD:290435	57/124 (46%)
Gdap2	NP_034399.1	Macro_GDAP2_like	54..193	CDD:239233	63/138 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..275		8/26 (31%)
		CRAL_TRIO_2	350..481	CDD:372686	62/130 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848759
Domainoid	1	1.000	135	1.000	Domainoid score	I4979
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7728
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2097
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55405
OrthoDB	1	1.010	-	-		D564346at33208
OrthoFinder	1	1.000	-	-		FOG0007360
OrthoInspector	1	1.000	-	-		oto92541
orthoMCL	1	0.900	-	-		OOG6_105245
Panther	1	1.100	-	-	LDO	PTHR11106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4847
SonicParanoid	1	1.000	-	-		X5478
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800