DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdap2 and MACROD2

DIOPT Version :9

Sequence 1:	NP_724597.1	Gene:	Gdap2 / 59173	FlyBaseID:	FBgn0042135	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001338590.1	Gene:	MACROD2 / 140733	HGNCID:	16126	Length:	448	Species:	Homo sapiens

Alignment Length:	302	Identity:	80/302 - (26%)
Similarity:	130/302 - (43%)	Gaps:	47/302 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KDVNNRFVIWDGDMTTLEVDAITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVR 127
            |.:..:..::.||:|.||||||.|.::.:|.....:...|...||..|..| ...:..|.||..:
Human    66 KSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAE-CRNLNGCDTGHAK 129

  Fly   128 ITRGYNLPAKYVLHTVAPAYREKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPA 192
            ||.||:||||||:|||.|..|.....:.:..|..||::.|...||.|:.::|...||.....||.
Human   130 ITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPN 194

  Fly   193 DVAAHIALRTIRRYLDKCTLQV--VILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGG 255
            :.||.|||.||:.:|.|...:|  :|.||      ..||...:|               .|.:..
Human   195 EPAAVIALNTIKEWLAKNHHEVDRIIFCV------FLEVDFKIY---------------KKKMNE 238

  Fly   256 EFGEPQHPDPDRQIRIIRNPQHSVHMRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYS 320
            .|....:.:.:..:.:               .:|||.:..:.:.:..::|..::|.:|::..:..
Human   239 FFSVDDNNEEEEDVEM---------------KEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVP 288

  Fly   321 SGLQAQLQRDLDRQHLLSDRPRTGVYENVISEGVEGIEHQER 362
            .....:...|...:....|       || |::|.|..:|..|
Human   289 GPASEEAVEDCKDEDFAKD-------EN-ITKGGEVTDHSVR 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	YmdB	67..234	CDD:225021	61/168 (36%)
		Macro_GDAP2_like	67..207	CDD:239233	53/139 (38%)
		CRAL_TRIO_2	393..518	CDD:290435
MACROD2	NP_001338590.1	Macro_Appr_pase_like	71..237	CDD:239236	63/187 (34%)
MACROD2	NP_001338590.1	MDN1	<263..448	CDD:331582	12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D564346at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820