Protein Alignment Gdap2 and MACROD2

DIOPT Version :10

• Sequence 1: NP_724597.1
• Gene: Gdap2 / 59173
• FlyBaseID: FBgn0042135
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001338590.1
• Gene: MACROD2 / 140733
• HGNCID: 16126
• Length: 448
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 80/302 - (26%)
• Similarity: 130/302 - (43%)
• Gaps: 47/302 - (15%)

  Fly    63 KDVNNRFVIWDGDMTTLEVDAITNTSDETLTESNSISERIFAVAGNQLREELSTTVKECRTGDVR 127
            |.:..:..::.||:|.||||||.|.::.:|.....:...|...||..|..| ...:..|.||..:
Human    66 KSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAE-CRNLNGCDTGHAK 129

  Fly   128 ITRGYNLPAKYVLHTVAPAYREKFKTAAENTLHCCYRNVLCKAKELNLHTIALCNISAHQKSFPA 192
            ||.||:||||||:|||.|..|.....:.:..|..||::.|...||.|:.::|...||.....||.
Human   130 ITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPN 194

  Fly   193 DVAAHIALRTIRRYLDKCTLQV--VILCVGSSERGTYEVLAPLYFPRDQLEERSALWQLPKDIGG 255
            :.||.|||.||:.:|.|...:|  :|.||      ..||...:|               .|.:..
Human   195 EPAAVIALNTIKEWLAKNHHEVDRIIFCV------FLEVDFKIY---------------KKKMNE 238

  Fly   256 EFGEPQHPDPDRQIRIIRNPQHSVHMRHHLADDDSDVSPHDMEGNSSDLEYGARDMNGLSLNSYS 320
            .|....:.:.:..:.:               .:|||.:..:.:.:..::|..::|.:|::..:..
Human   239 FFSVDDNNEEEEDVEM---------------KEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVP 288

  Fly   321 SGLQAQLQRDLDRQHLLSDRPRTGVYENVISEGVEGIEHQER 362
            .....:...|...:....|       || |::|.|..:|..|
Human   289 GPASEEAVEDCKDEDFAKD-------EN-ITKGGEVTDHSVR 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gdap2	NP_724597.1	Macro_GDAP2-like	67..234	CDD:394876	61/168 (36%)
		CRAL_TRIO_2	393..524	CDD:463965
MACROD2	NP_001338590.1	Macro_OAADPr_deacetylase	71..237	CDD:438955	63/187 (34%)