DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Capr and CAPRIN2

DIOPT Version :9

Sequence 1:	NP_001287107.1	Gene:	Capr / 59172	FlyBaseID:	FBgn0042134	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001002259.1	Gene:	CAPRIN2 / 65981	HGNCID:	21259	Length:	1127	Species:	Homo sapiens

Alignment Length:	1033	Identity:	226/1033 - (21%)
Similarity:	377/1033 - (36%)	Gaps:	290/1033 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GVATTNGQSNSSAAATADGS--QTDLASSNNNGNAAKSKANAVSAAAVVPEPYNP-LKQLLVTIE 117
            |..:.:|.|..........:  |.:.:....:..|.....:.:|:||...:.|.. ::..|:.::
Human    66 GYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLK 130

  Fly   118 HKIRNLEKRKTKLESYRAIQSSGKELSGDQASAVAKYDAVLANLEFARELAKHIQQQSKEAEKEQ 182
            |||||:||:|.|||.|:....||:.|:.||..||.||:.||.|||||:||.|.....|.:..|.|
Human   131 HKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQ 195

  Fly   183 KKQARKDNLAKTIAETAKIREVLIIQNVLNCFNDDQVRSDFLNGENGAKKLENTELELLEKFFIE 247
            ||..|::::.|..||..|:|.:|.:|.||.....:.|:.||..|.|||..|.:.||:.|.||
Human   196 KKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKF--- 257

  Fly   248 TQTRRPETADDVSFIATAQKSAELFYSTINARPKSFGEVSFEKLRSLFQQIQDSGYLD------- 305
            ::...||..:.:|.....::|:..|:..:....|:....:::.|:.|..::.:|||.:
Human   258 SKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKN 322

  Fly   306 -KYYLVPLAENAVANS---TDSGTGSGDGESGDLLNDGSGELDAELPSEPSARNSLEEGLDKLHL 366
             |...|||.|..:..|   |.........||..|:.....|:      :|      :|.|::.::
Human   323 AKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEI------QP------QEFLNRRYM 375

  Fly   367 GVQAELDQHQSYQQQQERPSHLLEPQHQRAPSLEHQQNSMVQQVSTQVYQAAPQAGGTTTPVHVL 431
               .|:|  .|.:|.:|:|   .|..:.|.|:|..:.:.:.:
Human   376 ---TEVD--YSNKQGEEQP---WEADYARKPNLPKRWDMLTE----------------------- 409

  Fly   432 YAPAPPAQQQPQQ-----PPPHPHQLLSSP-VNLQALQTGTA-----APPAQQQQ------PHPT 479
                |..|::.|:     .....||.:|.| |:|:..:..|:     .|..|::|      |.|:
Human   410 ----PDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPS 470

  Fly   480 HFAPNVRAVEQNYFKQPPQHPQGPGIQAPQTPQQQQFMQHSRPLAEVLGTGRFHFLQDSELDNPE 544
            .:..:....:..|.::..:..:.|.:...|..::                      ||.:...|:
Human   471 QWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKE----------------------QDPKKQTPK 513

  Fly   545 ALAPPPPTNQG--------LVFEQQPQQP-------NHVEEPTQAILTLTFTNQSFPSQQPQPQQ 594
            :..|...:.|.        :..||..:||       |:||....::     |:||    |..|:.
Human   514 SWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSL-----TSQS----QISPKS 569

  Fly   595 QGPQQQQQLFSPVLIHEQRQQPPQQQPQPMLIMPRLPTQQPQQPAPQGIGMQAGDVTSGFSYENA 659
            .|......:.:..|:..:....|:..|:|:           .||           |.|..:....
Human   570 WGVATASLIPNDQLLPRKLNTEPKDVPKPV-----------HQP-----------VGSSSTLPKD 612

  Fly   660 VVSYEQQIQQQLKQQQQQQQQQQQNLQQLDEPSSVNSSS---SVGAGGDVENNEWHARNND---- 717
            .|..::::|..:.|.|......|:::...|:|||...:|   |...|..|.:.|.:..:..
Human   613 PVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQ 677

  Fly   718 --------------------TNAAATAALTNVLKGETTQAT-PPA----------PPTKWSSEMN 751
                                |:.|::.:.|..:..||.:|. ||.          ||....||..
Human   678 EPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQG 742

  Fly   752 AMSSAASNGS--SNTSHKQEWAT---------PRDHS-------TGGGNSGYADNN--------- 789
            ..|..||:.|  .||:..|...|         ||...       :.|.|..:...:
Human   743 FQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQL 807

  Fly   790 -----ESNNHWNNSQGDGRRNSGNYQRRG---------------------------GDRDN-RDR 821
                 |...|       .:..:.||...|                           ..|.: |..
Human   808 PSIHVEQTVH-------SQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGC 865

  Fly   822 DQGGR---GDERRNGGDRG--NYRSRQYGNSSNTNGRNSGNSSGVYFRNNESGNGGGNNYYQNGG 881
            .:|||   ...|..||.:|  .||    |..|.:|    ||.|.:.|:..|.   .|..|.|..
Human   866 TRGGRLITNSYRSPGGYKGFDTYR----GLPSISN----GNYSQLQFQAREY---SGAPYSQRD- 918

  Fly   882 GGGGTYNKESRYESSGGGGGSYRGQRGG--------NQQRNVNGSYGGGRPMGDRGRG 931
                  |.:..|:..|..||.....|.|        :.:|: |.::..    ||.|:|
Human   919 ------NFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERD-NETFNS----GDSGQG 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Capr	NP_001287107.1	PRK12704	<109..>199	CDD:237177	41/89 (46%)
Capr	NP_001287107.1	Caprin-1_dimer	187..305	CDD:408102	34/117 (29%)
CAPRIN2	NP_001002259.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..108		4/40 (10%)
		SCP-1	<88..540	CDD:114219	126/523 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..614		51/314 (16%)
		Caprin-1_C	628..929	CDD:289087	64/325 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..753		24/110 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..975		12/49 (24%)
		C1q	999..1124	CDD:278798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159555
Domainoid	1	1.000	76	1.000	Domainoid score	I8979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003943
OrthoInspector	1	1.000	-	-		otm42256
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22922
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	8.020