DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Capr and caprin2

DIOPT Version :9

Sequence 1:	NP_001287107.1	Gene:	Capr / 59172	FlyBaseID:	FBgn0042134	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001013291.1	Gene:	caprin2 / 407729	ZFINID:	ZDB-GENE-040812-2	Length:	914	Species:	Danio rerio

Alignment Length:	883	Identity:	175/883 - (19%)
Similarity:	316/883 - (35%)	Gaps:	203/883 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SNSSAAATADGSQTDLASSNNNGNAAKSKANAVSAAAVV---------PEPYNPLKQLLVTIEHK 119
            |.|....|...|:..:...:..|:........:||..:.         .|.|  ::..|:.::||
Zfish    11 SPSRTLETLTPSELTVEKDDGQGSPKPESPRMLSALQLALSSTTVYCGYEKY--IEDGLICLKHK 73

  Fly   120 IRNLEKRKTKLESYRAIQSSGKELSGDQASAVAKYDAVLANLEFARELAKHIQQQSKEAEKEQKK 184
            |||:||:|.|||.|......|::|:.||..||.|||.|:.||:||:||.|.|...:::..|.|:|
Zfish    74 IRNIEKKKLKLERYSDKLKKGEKLNEDQLEAVGKYDEVVHNLKFAKELQKTIGSLTQDLLKAQRK 138

  Fly   185 QARKDNLAKTIAETAKIREVLIIQNVLNCFNDDQVRSDFLNGENGAKKLENTELELLEKFFIETQ 249
            ..|::...||..|.:::..:|.:|.||:....:.||.:|.|....:..:...::|.|........
Zfish   139 AVRQEKQMKTDEEKSRLSLMLQVQYVLHSLQREDVRKNFCNTRQYSCYMSTQDMEGLMDLASLVG 203

  Fly   250 TRRPETADDVSFIATAQKSAELFYSTINARPKSFGEVSFEKLRSLFQQIQDSGYLDKYYLVPLAE 314
            .:|..:   :|.....:::|.:::..:....|.....:::.::....::.|||:.|.   :||.:
Zfish   204 CKRDYS---ISLEDQMRRAAIVYWELLEGNEKPVAGSTYKHMKEKLLRLVDSGFFDN---IPLPK 262

  Fly   315 NAVANSTDSGTGSGDGESGDLLNDGSGELDAELPSEPSARNSLEEGLDKLHLGVQAELDQHQSYQ 379
            :.....|::                   :..:..|.||...:|.: |....:..:..|::....:
Zfish   263 SDSQEKTET-------------------IKPDSQSRPSGLTTLVK-LSSNEVPSKEFLNRRYMPE 307

  Fly   380 QQQERPSHLLEPQHQRAPSLEHQQNSMVQQVSTQVYQAAPQAGGTTTPVHVLYAPAPPAQQQPQQ 444
            ..:.|......|::.:...|     :|.::.....::....|.             |||..|...
Zfish   308 TDERRRGETASPRNWKEDFL-----AMKEREPPDSWEMEELAD-------------PPASSQSPI 354

  Fly   445 PPPHPHQLLSSPVNLQALQTGTAAPPAQQQQPHPTHFAPNVR-AVEQNYFKQPPQHPQGPGIQAP 508
            ..|........|..:..::..|..|..::|:......:.::. |||  .|..|...|:.| :|..
Zfish   355 QKPWKGAAGLIPKTVDIVKRSTTDPKEKRQRKKAEQDSKSMPVAVE--VFSSPSPLPKDP-VQRR 416

  Fly   509 QTPQQQQFMQHSRPLAEVLGTGRFHFLQDSELDNPEALAPPPPTNQGLVFEQQPQQPNHVEEPTQ 573
            |  |.:..|...        :|.|.|:|:|.||...:     |.|
Zfish   417 Q--QLETLMDQI--------SGSFSFMQESLLDGESS-----PVN-------------------- 446

  Fly   574 AILTLTFTNQSFPSQQPQPQQQGPQQQQQLF---SPVLIHEQRQQPPQQQPQPMLIMPRLPTQQP 635
                 |.|.:.    :|.|....|..|::|.   |.:|       |..|:..|:.|:..
Zfish   447 -----TQTKRC----RPSPGSSTPIVQRELTKSPSDIL-------PSSQRSTPLRILLS------ 489

  Fly   636 QQPAPQGIGMQAGDVTSGFSYENAVVSYEQQIQQQLKQQQQQQQQQQQNLQQLDEPSSVNSSSSV 700
                    |...|.:::|   :.::...:.::..:.|.::|        .:..:.|......||:
Zfish   490 --------GEGKGCLSNG---DRSINGSDLELHSEDKPRKQ--------AEGFNSPPLYRRGSSI 535

  Fly   701 GAGGDVENNEWHARNNDTNAAATAALTNVLKGETTQATPPAPPTKWS-----------SEMNAMS 754
            ...         ..|..|..|....|.|.:....:..|...||::.|           |..|.:.
Zfish   536 SVS---------LENQSTVQAGRQMLCNGVSSSGSAQTFSTPPSRRSISAENPFHNIHSVFNVIG 591

  Fly   755 -----SAASNGSSNTSHKQEWATPRDHSTGGGNSGYADNNESNNHWNNSQGDGRRNSGNYQ---- 810
                 .|..:|.|.:.|       |..::...:|....:.::....|..:.| .:..|.|.
Zfish   592 ESSGMKADESGFSESIH-------RSFTSAKTSSVTTASTQTPPELNPPEED-LQIEGQYPLECA 648

  Fly   811 -RRGGDRDNRDRDQGGRGDERRNGGDRGNYRSRQYGNSSNTNGRNSGNS----------SGVYFR 864
             ..||...:....:.|:....| |..||.|      ::...|.|:.|.|          |.:|..
Zfish   649 VSAGGPVFSSSHSRVGQSCYSR-GAVRGGY------DAYRVNVRSPGGSFMSQTHREPASALYMA 706

  Fly   865 NNESGNGGGNNYYQNGGGGGGTYNKESRYESSGGGGGS 902
            ..       |.|.||...|.||..:.|   |:|....|
Zfish   707 RE-------NGYQQNFKRGAGTATQRS---SAGWSDSS 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Capr	NP_001287107.1	PRK12704	<109..>199	CDD:237177	38/89 (43%)
Capr	NP_001287107.1	Caprin-1_dimer	187..305	CDD:408102	21/117 (18%)
caprin2	NP_001013291.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..283		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..326		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..411		9/45 (20%)
		Caprin-1_C	428..720	CDD:289087	70/388 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..480		13/81 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..529		4/44 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..631		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..747		7/20 (35%)
		C1q	786..911	CDD:278798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4539
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003943
OrthoInspector	1	1.000	-	-		otm24751
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22922
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.070