Protein Alignment Capr and CAPRIN1

DIOPT Version :10

• Sequence 1: NP_652671.1
• Gene: Capr / 59172
• FlyBaseID: FBgn0042134
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_005889.3
• Gene: CAPRIN1 / 4076
• HGNCID: 6743
• Length: 709
• Species: Homo sapiens
• Alignment Length: 862
• Identity: 206/862 - (23%)
• Similarity: 304/862 - (35%)
• Gaps: 236/862 - (27%)

  Fly    46 IPGTAVAAGAGVATTNGQSNSSAAATADGSQTDLASSNNNGNAAKSKANAVSAAAVVPEPYNPLK 110
            :|.....:|:|       |.||......||....|::.....|..|:..|....||..|   .:|
Human     1 MPSATSHSGSG-------SKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTE---AMK 55

  Fly   111 QLLVTIEHKIRNLEKRKTKLESYRAIQSSGKELSGDQASAVAKYDAVLANLEFARELAKHIQQQS 175
            |:|..|:.|:|||||:|.||:.|:...:.|:.|:.||..||:||..|..|||||:||.:.....|
Human    56 QILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALS 120

  Fly   176 KEAEKEQKKQARKDNLAKTIAETAKIREVLIIQNVLNCFNDDQVRSDFLNGENGAKKLENTELEL 240
            ::.:|..||.||::.|.:..||..:::.||.:|.||:...||:||:|...|.||...|...||.|
Human   121 QDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSL 185

  Fly   241 LEKFFIETQTRRPETADDVSFIATAQ-KSAEL-FYSTINARPKSFGEVSFEKLRSLFQQIQDSGY 303
            |::|:......|     |:|.....| :.|.: .:..:..:.|.....:::.|:.:.:::..|.|
Human   186 LDEFYKLVDPER-----DMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNY 245

  Fly   304 LDKYYLVPLAENAVANSTDSGTGSGDGESGDLLNDGSGELDAELPSEPSARNSLEEGLDKLHLGV 368
            .|..:          |..:......:..|...:.|...|.:.| |:|.....|..|..:.::...
Human   246 FDSTH----------NHQNGLCEEEEAASAPAVEDQVPEAEPE-PAEEYTEQSEVESTEYVNRQF 299

  Fly   369 QAE------------------LDQHQSYQQQQERPS------HLLEPQHQRAPSLEHQQNSMVQQ 409
            .||                  ::...|.|||.:..|      |.|.|..|..|.:..|:   ||.
Human   300 MAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQR---VQD 361

  Fly   410 VSTQV---YQAAPQA-----GGTTTPVHVLYAPAPPAQ--QQPQQ--PPPHPHQLLSSPVNLQAL 462
            :..|:   |.....:     ..|..|..|...|..|.|  ..||.  ||.|....|:.|..:...
Human   362 LMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQ 426

  Fly   463 QTGTAAP---------PAQQQQPHPTHFAPNVRAVEQNYFKQPPQHPQGP-GIQAPQTPQQQQFM 517
            ...|..|         .|.|....|:|      |.||...|:|....|.. .:...||.......
Human   427 PEATQVPLVSSTSEGYTASQPLYQPSH------ATEQRPQKEPIDQIQATISLNTDQTTASSSLP 485

  Fly   518 QHSRPLAEVLGTGR-------------FHFLQDSELDNPEALAPPPPTNQGLVFEQQPQ-QPNHV 568
            ..|:|.....||.:             |..:|.....|    ||.||.|:....:||.| |.::
Human   486 AASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMN----APVPPVNEPETLKQQNQYQASY- 545

  Fly   569 EEPTQAILTLTFTNQSFPSQQPQPQQQGPQQQQQL--------FSPVLIHE---QRQQPPQQQPQ 622
                         |||| |.||...:|...||:||        .||...|:   ..||||||
Human   546 -------------NQSF-SSQPHQVEQTELQQEQLQTVVGTYHGSPDQSHQVTGNHQQPPQQ--- 593

  Fly   623 PMLIMPRLPTQQPQQPAPQGIGMQAGDVTSGFSYENAVVSYEQQIQQQLKQQQQQQQQQQQNLQQ 687
                                        .:||...|                           |.
Human   594 ----------------------------NTGFPRSN---------------------------QP 603

  Fly   688 LDEPSSVNSSSSVGAGGDVENNEWHARNNDTNAAATAALTNVLKGETTQATPPAPPTKWSSEMNA 752
            ......|:...|.||.|                     |.|..:|         |...:....:.
Human   604 YYNSRGVSRGGSRGARG---------------------LMNGYRG---------PANGFRGGYDG 638

  Fly   753 MSSAASNGSSNTSHKQEWATPRDHSTGGGNSGYADNNESNNHWNNSQGDGRRNSGNYQRRGGDRD 817
            ...:.||..::...:.:::.|||:      |||             |.||.:.  |::|..|...
Human   639 YRPSFSNTPNSGYTQSQFSAPRDY------SGY-------------QRDGYQQ--NFKRGSGQSG 682

  Fly   818 NRDRDQGGRGDERRNGG 834
            .|...:|..|..|.|.|
Human   683 PRGAPRGRGGPPRPNRG 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Capr	NP_652671.1	PRK12704	<109..>199	CDD:237177	39/89 (44%)
		Caprin-1_dimer	187..305	CDD:436391	32/119 (27%)
		PRK11634	<802..858	CDD:236941	10/33 (30%)
CAPRIN1	NP_005889.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		13/55 (24%)
		Caprin-1_dimer	132..247	CDD:436391	32/119 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..291		7/31 (23%)
		Caprin-1_C	359..681	CDD:463522	95/455 (21%)
		G3BP1-binding. /evidence=ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:36279435	360..381		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	417..446		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..499		6/23 (26%)
		Disordered. /evidence=ECO:0000269|PubMed:31439799	524..709		63/300 (21%)