DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Capr and caprin2

DIOPT Version :9

Sequence 1:	NP_001287107.1	Gene:	Capr / 59172	FlyBaseID:	FBgn0042134	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_002942296.3	Gene:	caprin2 / 100145510	XenbaseID:	XB-GENE-1014055	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	921	Identity:	185/921 - (20%)
Similarity:	315/921 - (34%)	Gaps:	287/921 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LVTIEHKIRNLEKRKTKLESYRAIQSSGKELSGDQASAVAKYDAVLANLEFARELAKHIQQQSKE 177
            |:.::|||||:||:|.||:.||...|||:.|:.||..||.||:.|:.||:|||||.|.....|::
Frog    55 LICLKHKIRNIEKKKVKLDDYRDRLSSGEALNQDQQEAVEKYEEVVHNLDFARELQKTFSALSQD 119

  Fly   178 AEKEQKKQARKDNLAKTIAETAKIREVLIIQNVLNCFNDDQVRSDFLNGENGAKKLENTELELLE 242
            ..|.|||..|:::|.|..||..:::.:|.:|.:|:....|.|:.||..|.|||..|...:.:.|.
Frog   120 LLKAQKKALRREHLLKVEAEKKRLKAILQVQYMLHALCQDHVQKDFKEGSNGAVSLSPKDTDHLV 184

  Fly   243 KFF-IETQTRRPETADDVSFIATAQKSAELFYSTINARPKSFGEVSFEKLRSLFQQIQDSGYLDK 306
            ||. :..|.|.|.    :|......:::...::...:..|:....|::.|:.|..::.|.||.:.
Frog   185 KFAKLTCQKRYPH----MSLEDQMDQASICLWNLFESSEKTVAGTSYKYLKELVTKLLDCGYFEN 245

  Fly   307 YYLVPLAENAVANSTDSGTGSGDGESGDLLNDGSGELDAELPSEPSARNSLEEGLDKL------- 364
               ||  |..|..:.:.                  .:...||::..|.||:.:..:.|
Frog   246 ---VP--EAPVEKAKEK------------------HIPEVLPTKVEAGNSVTKEPEPLKEYAKCA 287

  Fly   365 ---------HL--------GVQAELDQHQSYQQQQERP--------------------------S 386
                     |.        .|:...:::::...:..||                          :
Frog   288 SHPKELPVRHFVAIAPKPEAVKQNTEEYKAINAKYCRPEALKPWGMSLEIRHPEPRRPNPTPVLT 352

  Fly   387 HLLEPQHQRAPSLE------HQQNSMVQQVSTQVYQAAPQAGGTTTPV----------HVLYAPA 435
            .|::|.....|.|:      .::...|.:..::|....|:......||          ..|..|.
Frog   353 PLIKPWEVMPPRLKKCDPDPKERRERVPKFPSEVKPVVPKFPSEVKPVASIKLLSKGLKDLKLPN 417

  Fly   436 PPAQQQP---QQPPPHPHQLLSSPVNLQALQTGTAAPPAQQQQPHPTHFAPNVRAVEQNYFKQPP 497
            ....|.|   |:.||            ..:..|...||....|||      .|..:..:.|...|
Frog   418 AVNGQLPVKRQEAPP------------TIVANGQPPPPVSSTQPH------KVPLLALDEFCSSP 464

  Fly   498 QHPQGPGIQAPQTPQQQQFMQHSRPLAEVLGTGRFHFLQDSELD----NPEALAPPPPTNQGLVF 558
            ..|:.|.::          .|....|.:.: .|.::|:|||.||    :|..::...|.....|.
Frog   465 TLPKDPELR----------KQRLEDLIDQI-KGTYNFMQDSMLDFDLSSPRLISSKLPCETTSVV 518

  Fly   559 EQQPQQ------------------------------PNHVEEPTQAILTLTFTNQSFPSQQPQPQ 593
            ..:.:|                              .:.:.||    |..|...::.|......:
Frog   519 SSETKQDETDPVLQLEEVSPVSLDTKEDGVACEMLSESAISEP----LAPTPLKENLPVNTSDEE 579

  Fly   594 QQGPQQQQQLFSPVLIHEQRQQPPQQQPQ------PM----LIMPRLPTQ----QPQQPAPQGIG 644
            |..|.:|        :.|.||..|:..|:      ||    |..|:.||.    |.||..|. :.
Frog   580 QSCPIEQ--------MAEARQDLPETLPERNNTPLPMGSDQLPSPKTPTHTSVLQLQQQCPP-LS 635

  Fly   645 MQAGDVTSGFSYENAVVSYEQQIQQQLKQQQQQQQQ----------------------------- 680
            .::..|:....::.....::......|.::|:.:.:
Frog   636 PRSTPVSMSSPFQGMQTVFKVNAPLPLHKEQELKVEAPYSTGYHQTFTTASTQTLPHCMLDTSFG 700

  Fly   681 QQQNLQQLDEPSSVNSSSSVGAGGDVENNEWHARNNDTNAAATAALTNVLKGETTQATPPAPPTK 745
            .|.:|.|...|.|...|:.:...|.:              ....:..|:|    .:.|||...::
Frog   701 DQNSLIQEPLPGSPYPSTGIQVNGSL--------------PCYTSSPNLL----PRMTPPFVSSR 747

  Fly   746 WSSEMNAMSSAASNGSSNTSHKQEWATPRDHSTGGGNSGYAD----NNESNNHWNNSQGDGRR-- 804
            .:....:.....:||         :..|..:.   |...|..    ||.|..|   .|..||.
Frog   748 GTIRGTSRGRVMTNG---------YRCPTGYK---GPESYRGAQCINNGSFAH---GQCPGREYP 797

  Fly   805 ---------NSGNYQRRGGDRDNRDRDQGGRGDERRNGGDRGNYRSRQYGNSSNTNGRNSGNSSG 860
                     :|..:.:||.:...|                   ..||.:..|...|..:..:|
Frog   798 ATQFIPRDGSSTLFHKRGTNTITR-------------------MNSRGFSESPQMNSPDKEDS-- 841

  Fly   861 VYFRNNESGNG 871
              |.:.:||:|
Frog   842 --FNSTDSGHG 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Capr	NP_001287107.1	PRK12704	<109..>199	CDD:237177	42/85 (49%)
Capr	NP_001287107.1	Caprin-1_dimer	187..305	CDD:408102	31/118 (26%)
caprin2	XP_002942296.3	Caprin-1_dimer	129..244	CDD:408102	31/118 (26%)
		Caprin-1_C	477..816	CDD:403488	64/385 (17%)
		C1q	884..1009	CDD:395310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11195
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003943
OrthoInspector	1	1.000	-	-		otm49486
Panther	1	1.100	-	-	O	PTHR22922
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.130