DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18810 and AKR2

DIOPT Version :9

Sequence 1:	NP_652670.2	Gene:	CG18810 / 59171	FlyBaseID:	FBgn0042133	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	224	Identity:	43/224 - (19%)
Similarity:	92/224 - (41%)	Gaps:	41/224 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LFLFILCGLPAIYYVLMEIILP-ELSDYWSPGYVFQL--LLGLFLFSNVMSNYVMCILVDPSID- 79
            |||...|.|   .|:..:.:.| .:|||......|.:  .|.:.||..::.:...|:..|.|:.
Yeast   367 LFLSTFCFL---IYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTS 428

  Fly    80 -PKLMKNQLVRGQHSEDWHECDKCGILAPPRSRHCRKCGVCVLMRDHHCFFTGCCIGHENYRYFF 143
             .:.:|..:..|:...: :.|.:.....|.||::....|..|...||:|.:....:|.:|::.|.
Yeast   429 IQETIKQLIDLGKFDRE-NFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFV 492

  Fly   144 YFLI------YFFLSCMISLTSSSIFIY----------------VLHGGRYQ---LFMLTHPAPN 183
            :|.:      :.|:...::....:.:||                :..|..|.   .|:....:.|
Yeast   493 FFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVN 557

  Fly   184 SAYFNSLIIRIIYFKL------PDIYELV 206
            ..:..:::| :.:|::      |:::.|:
Yeast   558 FIWLGAMLI-VQFFQILKGITTPELFILI 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18810	NP_652670.2	zf-DHHC	92..>138	CDD:303066	10/45 (22%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	43/224 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810