DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18810 and Zdhhc1

DIOPT Version :9

Sequence 1:	NP_652670.2	Gene:	CG18810 / 59171	FlyBaseID:	FBgn0042133	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001365935.1	Gene:	Zdhhc1 / 70796	MGIID:	1918046	Length:	484	Species:	Mus musculus

Alignment Length:	279	Identity:	65/279 - (23%)
Similarity:	112/279 - (40%)	Gaps:	67/279 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RSLKN--IWPKEKLEQFLFLFILCGLPAIYYVLM--EIILPELSDYWSP-GYVFQLLLGLFLFSN 63
            ||.:|  .||...|:      |:..|..:::.::  .:::|.|..:|.| ||.   .:|. :|:.
Mouse    35 RSRRNGWSWPPHPLQ------IVAWLLYLFFAVIGFGVLVPLLPHHWVPAGYA---CMGA-IFAG 89

  Fly    64 VMSNYVMCILVDP---SIDPKLMKNQLV---RGQHS---EDWHECDKCGILAPPRSRHCRKCGVC 119
            .:..::..:.:||   ::..|.....|.   |.||:   ||.| |:.|.:....||:||..|..|
Mouse    90 HLVVHLTAVSIDPADANVRDKSYSGPLPIFNRSQHAHVIEDLH-CNLCDVDVSARSKHCSACNKC 153

  Fly   120 VLMRDHHCFFTGCCIGHENYRYFF------------------YFLIYFFLSCMISLTSSSIFIYV 166
            |...||||.:...|:|..|||.|.                  |..:.||::.|...|:....:..
Mouse   154 VCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLK 218

  Fly   167 LHGGRYQLFMLTHPAPNSAYFNSLIIRIIYFKLPDIYELVFTLVFV------LLWIGVCVATYVA 225
            .|...:.:|:...|....|              |.|..|...|:.:      ||...:|...|:.
Mouse   219 NHTDVWFVFLPAAPVETQA--------------PAILALAALLILLGLLSTALLGHLLCFHIYLM 269

  Fly   226 YDQWSRGYFCYDFELQNIP 244
            :.:.:    .|::.:|:.|
Mouse   270 WHKLT----TYEYIVQHRP 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18810	NP_652670.2	zf-DHHC	92..>138	CDD:303066	19/48 (40%)
Zdhhc1	NP_001365935.1	Mediates interaction with STING1. /evidence=ECO:0000250\|UniProtKB:Q8WTX9	1..268		61/257 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		2/2 (100%)
		DHHC	126..281	CDD:396215	40/173 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000