DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18810 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_652670.2	Gene:	CG18810 / 59171	FlyBaseID:	FBgn0042133	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	315	Identity:	70/315 - (22%)
Similarity:	100/315 - (31%)	Gaps:	105/315 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YWSPGYVFQLLLGLFLFSNV-------MSN---YVMCIL---------------------VDPSI 78
            ||.|.....||||...::..       |.|   .|:|::                     ::||.
Mouse    18 YWIPVVFISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSK 82

  Fly    79 DPKLM---KNQLVRGQHSEDWHE----------------------CDKCGILAPPRSRHCRKCGV 118
            :..|.   |..|.|....|...|                      ||:|.::.|.|..||..|..
Mouse    83 EFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDK 147

  Fly   119 CVLMRDHHCFFTGCCIGHENYRYFFYFLIYFFLSCM-ISLTSSSIFIYVLHGGRYQLFMLTHPAP 182
            |:|..||||.:...|:|..||::|..||.|..|.|: |:.|....||.....|
Mouse   148 CILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIRFWTNG------------ 200

  Fly   183 NSAYFNSLIIRIIYFKLPDI---YELVFTLVFVLLWIGVCVATYVAYDQWSRGYFCYDFELQNIP 244
                            |||.   :.::| |.|......|.:::...|..|.........|....|
Mouse   201 ----------------LPDTQAKFHIMF-LFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRNP 248

  Fly   245 ----------FDRKLRRNFKTFLGRRMKWTWISGFVPSQLDHDGF-----DLDPD 284
                      |.....:|.:...|...|: |:.....||.|...|     :.||:
Mouse   249 VFRHGTDKNGFSLGFSKNMRQVFGDEKKY-WLLPVFSSQGDGCSFPTCLVNQDPE 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18810	NP_652670.2	zf-DHHC	92..>138	CDD:303066	18/67 (27%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	39/149 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		2/7 (29%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366		2/5 (40%)
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810