DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18810 and Hip14

DIOPT Version :9

Sequence 1:	NP_652670.2	Gene:	CG18810 / 59171	FlyBaseID:	FBgn0042133	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	63/313 - (20%)
Similarity:	109/313 - (34%)	Gaps:	97/313 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FLFLFILCG-LPAIYYVLMEIILPE-------LSDYWSPGYVFQLLLGLFLFSNVMSNYVMCILV 74
            ::..|.|.| |.:|::.:.:.:..|       ||.|.:....|.:...:::...|.....:|.|:
  Fly   320 YIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLI 384

  Fly    75 DPSI-----------DPKLMKNQLVRGQHSEDWHE--------------CDKCGILAPPRSRHCR 114
            ...:           ||.:::.  .|.|..:...|              |..|.:..|.||:||.
  Fly   385 SSLLLWVCFLKSWKGDPGIIRP--TREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCS 447

  Fly   115 KCGVCVLMRDHHCFFTGCCIGHENYRYFFYFLIYFFLSCMISLTSSSIFIYVLHGGRYQLFMLTH 179
            .|..||...||||.:.|.|||.:|:.||..||....:.|          .::|:||
  Fly   448 VCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMC----------AWMLYGG--------- 493

  Fly   180 PAPNSAYFNSLIIRIIYFKLPDIYELVFTLVFVLLWIGVCVATYVAYDQW--------------- 229
               :..|.|...:|     ..|....:..:.....|:|..:...:.:..|
  Fly   494 ---SKYYVNQCNVR-----FDDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICL 550

  Fly   230 --------SRGYFCYDFELQ--NIPFDRKLRRNFKTFL---------GRRMKW 263
                    :||.:.: |:.:  :.||.|...:|...||         .:|:.|
  Fly   551 GMTTNERMNRGRYRH-FQAKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDW 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18810	NP_652670.2	zf-DHHC	92..>138	CDD:303066	19/59 (32%)
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	34/159 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900