DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18810 and Zdhhc13

DIOPT Version :9

Sequence 1:	NP_652670.2	Gene:	CG18810 / 59171	FlyBaseID:	FBgn0042133	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_082307.1	Gene:	Zdhhc13 / 243983	MGIID:	1919227	Length:	622	Species:	Mus musculus

Alignment Length:	280	Identity:	57/280 - (20%)
Similarity:	117/280 - (41%)	Gaps:	51/280 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKNIWPKEKL--EQFLFLFILCGLPAIYYVLME---IILPELSDYWSP---GYVFQLLLGLFLFS 62
            |.:::|:..:  :..::|..:..|.:|:::.|.   :..|:.:.  ||   .::|.::..|:.|.
Mouse   330 LTSLFPRFLVGYKNLVYLPTVFLLSSIFWIFMTWFILFFPDTAG--SPLYFAFIFSIMAFLYFFY 392

  Fly    63 NVMSNYVMCILVDP-----SIDPKLMKNQLVRGQHSEDWHE-CDKCGILAPPRSRHCRKCGVCVL 121
            ...:       .||     |.:.:.:....:....|.|:.. |..|.|..|.||.||..|..||.
Mouse   393 KTWA-------TDPGFTKASEEERKVNIVTLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVA 450

  Fly   122 MRDHHCFFTGCCIGHENYRYFFYFLIYFFLSCMISLTSSSIFIYVLHGGRYQLFMLTHPAPNS-- 184
            ..|.|||:||.|||..|:.::.:||          |:.|.:..::::|.  .::...|.|...
Mouse   451 RFDQHCFWTGRCIGFGNHHHYIFFL----------LSLSMVCDWIIYGS--FVYWSNHCATTFKE 503

  Fly   185 ----AYFNSLII---RIIYFKLPDIYE------LVFTLVFVLLWIGVCVATYVAYDQWSRGYFCY 236
                .|.|.::.   .::|..:...:.      |:...:|.:.::|:.....::..:.|| :...
Mouse   504 DGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSR-HMKQ 567

  Fly   237 DFELQNIPFDRKLRRNFKTF 256
            ...|:..|::....:|...|
Mouse   568 TLSLRKTPYNLGFTQNLADF 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18810	NP_652670.2	zf-DHHC	92..>138	CDD:303066	22/46 (48%)
Zdhhc13	NP_082307.1	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		Ank_2	86..179	CDD:289560
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK	176..>269	CDD:238125
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		Ank_5	202..257	CDD:290568
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..556	CDD:279823	35/144 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810