DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18788 and CG9254

DIOPT Version :9

Sequence 1:	NP_652665.3	Gene:	CG18788 / 59164	FlyBaseID:	FBgn0042126	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	179/562 - (31%)
Similarity:	276/562 - (49%)	Gaps:	122/562 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPAVEQ-----KLSDIFIYLEVRQRWVLCCFTFLAIINAYTMRLCLDCTLNRIILECGGHRVDN 60
            |..|.||     |||..|:   :.|||:|....|.||.||||||:||...:..::::
  Fly     1 MADAKEQPEWGIKLSKFFV---LPQRWILAIMGFFAIFNAYTMRICLSQAITVLVVK-------- 54

  Fly    61 VPQVLNPKALPNWRIELAMALNHTEYQLRSRLKAGKEQPDLNQISAKGTRDREPAGEKRPGQEDS 125
                      .|:.|      .|||...         :||         ...:|:.....|..|
  Fly    55 ----------RNYTI------FHTEAIC---------EPD---------DQSDPSSTFEGGDYD- 84

  Fly   126 QERLSCSEQWPRQTQSLVVMAFYAGYVLSHVPGGRLAERYGGKWVLSAAILTSAVLTLLTPTAVR 190
                     |.::.|.|::.:||.||:::|:|||.||:::||||.||..|..:|:.|||||..:.
  Fly    85 ---------WSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPVCIV 140

  Fly   191 QGGLYALVAVRLLVGICEGPCFPAVCALLAQWVPEQERGMLASCVLSGGEIGITMVQLVSGLLIA 255
            .||..||:.:|:|:|:.||..|||:..|||.|||..|||||.:.||.||::|.....::||.:::
  Fly   141 YGGADALIVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGYVLS 205

  Fly   256 EQDWPVFFYLVGGGAVAWFLGFTLVCYSTPDHCPFIQSEEREYIRCNTSNSFLLTTGREREEMDG 320
            ..|||..||:....|:.||:.|||||:|:|...|:|:.|||.::               .:|:..
  Fly   206 SMDWPWVFYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFL---------------AQEVPP 255

  Fly   321 EDGYEGEDREHRREVEATCNTAPWRSMLNSTPLWALVSTSMQQEF-----QQKLPQELQIALE-E 379
            .|..:.:              .|:.::|.|.|:|||:|..:..::     ...||:.:...|. .
  Fly   256 PDKNKPK--------------TPFFAILTSIPMWALISAQIGHDWGFYIMVSYLPKYMSDVLRFS 306

  Fly   380 VRARGTSFSELTTIIETIAPSVGNWIASLTTGRLSDVLIEQQILTRTQTRRLMSWLVFLCGSMYM 444
            :::.|. :|.|        |.|..||.||.:|.::|.:|::..::.|.||::|:.:.....:::|
  Fly   307 IKSNGL-YSSL--------PYVTMWIMSLLSGCVADQMIKRNCMSTTNTRKIMTGVAAFGPAVFM 362

  Fly   445 LQIKMSGARIWSVLG--------MGAYYASIKLLPLDMSPNYAGTLMGISGGMGALPALLMPYLE 501
            :....:|.....|:.        ||.|||.:||.|||||||||||||.|:.|:||:..::.|||.
  Fly   363 VAASYAGCNRGMVVALFTITMGLMGTYYAGMKLTPLDMSPNYAGTLMAITNGIGAITGVVSPYLV 427

  Fly   502 QLETDYKLVSSVRAAMWV----------IGASYISGDVQAFN 533
            .:.|....:...|...||          :...:.|||||.||
  Fly   428 GVMTPNATLLEWRLVFWVAFGVLVVTAIVYCIWASGDVQPFN 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18788	NP_652665.3	MFS	129..>280	CDD:119392	66/150 (44%)
CG18788	NP_652665.3	MFS_1	135..498	CDD:284993	132/376 (35%)
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	163/527 (31%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	140/426 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347586at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	8	7.970