DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18788 and slc-17.3

DIOPT Version :9

Sequence 1:	NP_652665.3	Gene:	CG18788 / 59164	FlyBaseID:	FBgn0042126	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_498709.2	Gene:	slc-17.3 / 182107	WormBaseID:	WBGene00015333	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	122/580 - (21%)
Similarity:	205/580 - (35%)	Gaps:	163/580 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLC-----CFTFLAIINAYTMRLCLDCTLNRIILECGGHRVDNVPQVLNPKALPNWRIELAMALN 82
            :||     |.||:.|..|.||    .|.:|...|     .|:|             .|:||...|
Worm    19 LLCMIGFFCTTFMRIHFALTM----TCMVNSTAL-----AVEN-------------EIKLAGNSN 61

  Fly    83 HTEYQLRSRLKAGKEQPDLNQISAKGTRDREPAGEKRPGQEDSQERLSCSEQWPRQTQSLVVMAF 147
            .:|..:...:..|..       ...|..|.:  |:|:...:...|.:     |....|:|:....
Worm    62 VSEISIIEEINLGSN-------GQCGLMDED--GQKKVVVDYGGELV-----WNSYEQNLIFSGT 112

  Fly   148 YAGYVLSHVPGGRLAERYGGKWVLSAAILTSAVLTLLTPTAVRQGGLYALVAVRLLVGICEGPCF 212
            :.|.:::.:|.....||:..:.||..::....::|::||......|.:::...|:.:|:.||..|
Worm   113 FWGSLITVLPSMFFIERFSPRHVLQISVALYILVTVITPFLATHFGYFSVFLARIGMGLGEGFVF 177

  Fly   213 PAVCALLAQWVPEQERGMLASCVLSGGEI----GITMVQLVSGLLIAEQDWPVFFYLVGGGAVAW 273
            |...|::..|.|..|:....|....|.:|    |..||..|..   ::..||..||..|..|..|
Worm   178 PTNNAIIGNWFPSSEKSTALSIFTLGNQIASAAGSPMVAAVCA---SDLGWPATFYFAGIFATGW 239

  Fly   274 FLGFTLVCYSTPDHCPFIQSEEREYIRCNTSNSFLLTTGREREEMDGEDGYEGEDREHRREVEAT 338
            .:.:.....|.|.....:..:|:||:..|...                       :.|:.|   .
Worm   240 SILWFFTASSHPAKVKMMTKKEKEYLLANVVK-----------------------KVHKSE---K 278

  Fly   339 CNTAPWRSMLNSTPLWA------LVSTSMQQEFQQKLPQELQIALE-EVRARGTSFSELTTIIET 396
            ..:.|:..:|.|.....      .|:..|.. ||..||...:..|. .|.|.||.         |
Worm   279 TRSIPYSKILTSPAFLGQLQCHFFVNLFMTL-FQIYLPSYFKEVLHLGVIANGTF---------T 333

  Fly   397 IAPSVGNWIASLTTGRLSDVLIEQQILTRTQTRRL-------------------------MSWLV 436
            ..|::.|.|..:..|...|.|.|.:||:.|:..::                         .:.|:
Worm   334 AIPNIFNMIFKVVWGIGIDKLKENKILSNTKAVKVSHGVASFGSSFSLILLAFFVDCSNPTTGLI 398

  Fly   437 FLCGSMYMLQIKMSGARIWSVLG--MGAYYASIKLLPLDMSPNYAGTLMGISGGMGALPALLMPY 499
            |.|             .::|.:|  :..:|.|:    |.::|.|..|:..||..:..:..|..|
Worm   399 FFC-------------LMYSSMGTFVSGFYTSL----LSLAPQYTATMSAISMFVAMIGRLTTP- 445

  Fly   500 LEQLETDYKLVSSVR----AAMW---VIGAS------------YISGDVQAFNQPEREPQ 540
                    .::|..|    ||.|   .||.|            :.||::|.:.:.|.:.:
Worm   446 --------AVMSMFRKDGTAAEWQNIFIGCSLAHIFSGSIFLLFGSGELQDWAKVEDDQE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18788	NP_652665.3	MFS	129..>280	CDD:119392	37/154 (24%)
CG18788	NP_652665.3	MFS_1	135..498	CDD:284993	84/400 (21%)
slc-17.3	NP_498709.2	2A0114euk	20..496	CDD:129972	122/576 (21%)
slc-17.3	NP_498709.2	MFS	90..481	CDD:119392	94/460 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910