DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and TMPRSS11D

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_004253.1	Gene:	TMPRSS11D / 9407	HGNCID:	24059	Length:	418	Species:	Homo sapiens

Alignment Length:	256	Identity:	80/256 - (31%)
Similarity:	108/256 - (42%)	Gaps:	58/256 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 GAENAELNEYPWMVLLLYENRL----SLIR--YVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDC 166
            |...||...:||.|.|...|..    |||.  ::|||||| ........|.:..|   |.|||
Human   189 GGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHC-FRSNSNPRDWIATS---GISTT-- 247

  Fly   167 ITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDLN 231
                  .|.|.:.|....:|..:.|:  |:.|||||:||:..|.:||.|..:||     |....|
Human   248 ------FPKLRMRVRNILIHNNYKSA--THENDIALVRLENSVTFTKDIHSVCL-----PAATQN 299

  Fly   232 L------QISGWDPTKSSQTLITSTVKERNPA-------DCLNRYPSFRSA---SQVCAGGQRKG 280
            :      .::||    .:|.....||.|....       |..|...|:..|   ..:|||..:.|
Human   300 IPPGSTAYVTGW----GAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG 360

  Fly   281 -DTCAGISGSPVMGIMGSGVDE----FVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIK 336
             |.|.|.||.|:       |.|    ..|:.||.|:|.| |.....|||||::..:.:||:
Human   361 VDACQGDSGGPL-------VQEDSRRLWFIVGIVSWGDQ-CGLPDKPGVYTRVTAYLDWIR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	80/256 (31%)
		Tryp_SPc	108..335	CDD:214473	78/253 (31%)
TMPRSS11D	NP_004253.1	SEA	48..143	CDD:279699
		Tryp_SPc	186..412	CDD:214473	78/253 (31%)
		Tryp_SPc	187..415	CDD:238113	80/256 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910