DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and Prss12

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_445956.1	Gene:	Prss12 / 85266	RGDID:	69238	Length:	761	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	100/355 - (28%)
Similarity:	139/355 - (39%)	Gaps:	97/355 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAECVRLS----SCQKDEKCTRLVSCSPLMNILRPRGMTQAEKDVFAHRQ-------CGLDPNGH 74
            ||:||:..    :|:..|...  |.|.            ..||....|..       |||
  Rat   462 LADCVKQDIGRHNCRHSEDAG--VICD------------YYEKKTSGHGNKETLSSGCGL----- 507

  Fly    75 ELLHMVYVCCPELGDVLPNKQTCGQTTPVFRDRGAENAELNEYPWMVLLLY-----ENRL----S 130
            .|||              .:||        |..|..|:....:||...|..     :.||    :
  Rat   508 RLLH--------------RRQT--------RIIGGNNSLRGAWPWQASLRLKSTHGDGRLLCGAT 550

  Fly   131 LIR--YVLTAAHCVIGGYLTQ--NDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTS 191
            |:.  :|||||||     .|:  |:....:||:|:..|  :..|..  ..|:.|.|..:|:.:..
  Rat   551 LLSSCWVLTAAHC-----FTRYGNNSRSYAVRVGDYHT--LVPEGF--EQDIGVQQIVIHRNYRP 606

  Fly   192 SGGTYRNDIALLRLQFP----VRYTKKIQPICL-LDAEFPLQDL-NLQISGWDPT--KSSQTLIT 248
            ....|  ||||:|||..    .|.:..:.|.|| |..|.|.:.. |..|:||..|  ..|:||..
  Rat   607 DSSDY--DIALVRLQGSGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDTGRAYSRTLQQ 669

  Fly   249 STVKERNPADCLNRYPSFRSASQVCAGG---QRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIAS 310
            :.|.......|..||....:...:|||.   ..:.|:|.|.||.|   :|....||...:.|:.|
  Rat   670 AAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGP---LMCEKPDETWVVYGVTS 731

  Fly   311 YGQQYCYSAGI---PGVYTKIGHFSEWIKA 337
            :|    |..||   |||||::..|..|||:
  Rat   732 WG----YGCGIKDTPGVYTRVPAFVPWIKS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	11/55 (20%)
		Tryp_SPc	108..338	CDD:238113	80/257 (31%)
		Tryp_SPc	108..335	CDD:214473	77/253 (30%)
Prss12	NP_445956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..89
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..266	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555	7/24 (29%)
		SRCR	391..485	CDD:278931	7/24 (29%)
		Zymogen activation region. /evidence=ECO:0000250	505..516		8/37 (22%)
		Tryp_SPc	516..755	CDD:214473	78/256 (30%)
		Tryp_SPc	517..758	CDD:238113	80/259 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910