DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PRSS27

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_114154.1	Gene:	PRSS27 / 83886	HGNCID:	15475	Length:	290	Species:	Homo sapiens

Alignment Length:	263	Identity:	69/263 - (26%)
Similarity:	111/263 - (42%)	Gaps:	40/263 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CGQTTPVFRDRGAENAELNEYPWMVLLLYENRL----SLI--RYVLTAAHCVIGGYLTQNDLVLK 155
            ||:...:.|..|.::.:..|:||.|.:......    |||  ::|||||||    :...::..|.
Human    26 CGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHC----FRNTSETSLY 86

  Fly   156 SVRLGESTTDCITSESRCPHLDV-EVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPIC 219
            .|.||  ....:.......:..| :|....::||..||.     |:||:.|:.||.:|..|.|:|
Human    87 QVLLG--ARQLVQPGPHAMYARVRQVESNPLYQGTASSA-----DVALVELEAPVPFTNYILPVC 144

  Fly   220 LLDAEFPLQ-DLNLQISGWDPTKSSQTLITSTVKER------NPADCLNRY---------PSFRS 268
            |.|.....: .:|..::||........|....:.::      :...|...|         |....
Human   145 LPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIK 209

  Fly   269 ASQVCAGGQR-KGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFS 332
            ...:|||.:. |.|.|.|.||.|::.::|    :....||:.|:|:. |.....||||.::....
Human   210 NDMLCAGFEEGKKDACKGDSGGPLVCLVG----QSWLQAGVISWGEG-CARQNRPGVYIRVTAHH 269

  Fly   333 EWI 335
            .||
Human   270 NWI 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	66/252 (26%)
		Tryp_SPc	108..335	CDD:214473	64/250 (26%)
PRSS27	NP_114154.1	Tryp_SPc	34..272	CDD:214473	65/253 (26%)
PRSS27	NP_114154.1	Tryp_SPc	36..275	CDD:238113	66/253 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910