DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and Klk12

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_081373.1	Gene:	Klk12 / 69511	MGIID:	1916761	Length:	247	Species:	Mus musculus

Alignment Length:	240	Identity:	74/240 - (30%)
Similarity:	105/240 - (43%)	Gaps:	47/240 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 NEYPWMVLLLYENRLS----LI--RYVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRC 173
            |..||.|.|.:...|.    |:  ::|||||||        .|..:  |||||.:...:....:.
Mouse    31 NSQPWQVGLFHGKYLRCGGVLVDRKWVLTAAHC--------RDKYV--VRLGEHSLTKLDWTEQL 85

  Fly   174 PHLDVEVGQTTVHQGFTSSGGTYRN---DIALLRLQFPVRYTKKIQPICLLDAEFPLQDLNLQIS 235
            .|       ||......|..|.|:|   |:.||||..|:..|:.::|:. |.:..........:|
Mouse    86 RH-------TTFSITHPSYQGAYQNHEHDLRLLRLNRPIHLTRAVRPVA-LPSSCVTTGAMCHVS 142

  Fly   236 GWDPTKSS--------QTLITSTVKERNPADCLNRYPSFRSASQVCAGGQRKGDTCAGISGSPVM 292
            ||..|...        |.|..|||....   |...:|...:.:.:||||:...|.|.|.||.|
Mouse   143 GWGTTNKPWDPFPDRLQCLNLSTVSNET---CRAVFPGRVTENMLCAGGEAGKDACQGDSGGP-- 202

  Fly   293 GIMGSGVDEFVFLAGIASYGQ-QYCYSAGIPGVYTKIGHFSEWIK 336
             ::..||     |.|:.|:|. ..|...||||||||:..:::||:
Mouse   203 -LVCGGV-----LQGLVSWGSVGPCGQKGIPGVYTKVCKYTDWIR 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	74/240 (31%)
		Tryp_SPc	108..335	CDD:214473	72/237 (30%)
Klk12	NP_081373.1	Tryp_SPc	21..240	CDD:214473	72/237 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910