DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and CELA2A

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_254275.1	Gene:	CELA2A / 63036	HGNCID:	24609	Length:	269	Species:	Homo sapiens

Alignment Length:	286	Identity:	81/286 - (28%)
Similarity:	124/286 - (43%)	Gaps:	57/286 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LGDVLPNKQTCGQTT-PVFRDR--GAENAELNEYPWMVLLLYENR--------LSLI--RYVLTA 138
            |..::....:||..| |.:..|  |.|.|..|.:||.|.|.|.:.        .|||  .:||||
Human     7 LSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTA 71

  Fly   139 AHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALL 203
            |||:...         ::.|:|....:...:||  ..|.|.|.:..||:.:.|:..:..||||||
Human    72 AHCISSS---------RTYRVGLGRHNLYVAES--GSLAVSVSKIVVHKDWNSNQISKGNDIALL 125

  Fly   204 RLQFPVRYTKKIQPICL------LDAEFPLQDLNLQISGW----------DPTKSSQTLITSTVK 252
            :|..||..|.|||..||      |...:|     ..::||          |..:..:.|:.
Human   126 KLANPVSLTDKIQLACLPPAGTILPNNYP-----CYVTGWGRLQTNGAVPDVLQQGRLLVV---- 181

  Fly   253 ERNPADCLNR--YPSFRSASQVCAGGQRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQY 315
              :.|.|.:.  :.|....|.:||||.....:|.|.||.|:......|..:   :.||.|:|.:.
Human   182 --DYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQ---VHGIVSFGSRL 241

  Fly   316 -CYSAGIPGVYTKIGHFSEWIKANLA 340
             |.....|.|:|::.::.:||.:.:|
Human   242 GCNYYHKPSVFTRVSNYIDWINSVIA 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	74/258 (29%)
		Tryp_SPc	108..335	CDD:214473	72/255 (28%)
CELA2A	NP_254275.1	Tryp_SPc	29..265	CDD:238113	74/260 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910