DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and c1s

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_002941253.2	Gene:	c1s / 613055	XenbaseID:	XB-GENE-995410	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	88/375 - (23%)
Similarity:	150/375 - (40%)	Gaps:	99/375 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSSCQKDE-------KCTRLVSC---SPLMN------------------------ILRPRGMTQA 57
            :|:||.|.       :| :||:|   .|:.|                        :..|.|
Frog   338 ISTCQGDGTWKNMHFQC-QLVNCGEPDPIDNGNVFSNTTTYGSEITYNCSDEYYALTLPAG---- 397

  Fly    58 EKDVFAHRQCG--LDPNGHELLHMVYVCCPELGDVLPNKQTCG--QTTPVFRDRGAENAELNEYP 118
            |...::....|  ::..|::.|.   :|.|          .||  |:....|..|...|:..::|
Frog   398 EDGTYSCSSYGYWVNSRGNKELP---ICTP----------VCGVHQSDKSGRIFGGTRAKPGQFP 449

  Fly   119 WMV----LLLYENRLSLIRYVLTAAHCV--------IGGYLTQNDLVLKSVRLGESTTDCITSES 171
            ||:    :.|....|...|:||||||.|        .||       |:|..    ..|:..:.|.
Frog   450 WMIQFTDIELGGGSLISDRWVLTAAHVVNKKIFPTMFGG-------VMKFF----PNTNLQSQEK 503

  Fly   172 RCPHLDVEVGQTTVHQGF-----TSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEF-PLQDL 230
            |     ::..:..:|..:     |.....:.|||||::|...|:....|.||||..... |:.:.
Frog   504 R-----LQAKKIIIHPLYQDNEDTEGQSNFDNDIALVQLTKKVKLGSCISPICLPRRGLAPVVNE 563

  Fly   231 NLQISGWDPTKSSQTLIT---STVKERNPADCLNRY--PSFRSASQVCAGGQRKGDTCAGISGSP 290
            ...|:||..|:..::.:.   :::...:...|....  ..:.:.:.:|||.....|:|.|.||.|
Frog   564 VATIAGWGKTEKRESAVNLQFASISLSSMDKCKKATGGKGYFTPNMLCAGSDVGKDSCNGDSGGP 628

  Fly   291 VMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANLA 340
            :| .........:::|||.|:|.:.|   |..|:|||:.::.:||:..:|
Frog   629 LM-FTDPQDSSKMYMAGIVSWGPRDC---GTYGLYTKVDNYLDWIEETIA 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	12/77 (16%)
		Tryp_SPc	108..338	CDD:238113	65/252 (26%)
		Tryp_SPc	108..335	CDD:214473	63/249 (25%)
c1s	XP_002941253.2	CUB	21..131	CDD:238001
		FXa_inhibition	145..173	CDD:405372
		CUB	177..288	CDD:238001
		PHA02927	301..>436	CDD:222943	21/115 (18%)
		Tryp_SPc	436..669	CDD:214473	64/252 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910