DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PRSS8

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens

Alignment Length:	267	Identity:	77/267 - (28%)
Similarity:	120/267 - (44%)	Gaps:	42/267 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CGQTTPVFRDRGAENAELNEYPWMVLLLYE------NRLSLIRYVLTAAHCVIGGYLTQNDLVLK 155
            || ..|..|..|..:|...::||.|.:.||      ..|...::||:||||    :.:::.....
Human    37 CG-VAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHC----FPSEHHKEAY 96

  Fly   156 SVRLGESTTDCITSESRCPHL-DVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPIC 219
            .|:||....|..:.:::...| |:     ..|..:...|.  :.|||||:|..|:.:::.|:|||
Human    97 EVKLGAHQLDSYSEDAKVSTLKDI-----IPHPSYLQEGS--QGDIALLQLSRPITFSRYIRPIC 154

  Fly   220 L--LDAEFPLQDLNLQISGWDPTKSSQTLITS--------TVKERNPADCLNRY------PSFRS 268
            |  .:|.|| ..|:..::||.....|.:|:|.        .:..|...:||...      |.|..
Human   155 LPAANASFP-NGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQ 218

  Fly   269 ASQVCAGGQRKG-DTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFS 332
            ...||||....| |.|.|.||.|    :...|:...:|.||.|:|.. |.:...|||||....::
Human   219 EDMVCAGYVEGGKDACQGDSGGP----LSCPVEGLWYLTGIVSWGDA-CGARNRPGVYTLASSYA 278

  Fly   333 EWIKANL 339
            .||::.:
Human   279 SWIQSKV 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	73/253 (29%)
		Tryp_SPc	108..335	CDD:214473	71/250 (28%)
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	72/253 (28%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	73/255 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910