DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	297	Identity:	92/297 - (30%)
Similarity:	139/297 - (46%)	Gaps:	51/297 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PNGHELLHMVYVCCPELGDVL----PNKQTCGQ------TTPVFRDRGAENAELNEYPWMVLLLY 125
            |:||.:|.....|   |.|.|    .|.::||:      .||  :..|..||:...:||:|.|.|
Human   790 PDGHLILTPSQQC---LQDSLIRLQCNHKSCGKKLAAQDITP--KIVGGSNAKEGAWPWVVGLYY 849

  Fly   126 ENRL----SLIR--YVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTT 184
            ..||    ||:.  ::::|||||.|..|..:..   :..||......:||....|.|   :.:..
Human   850 GGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKW---TAILGLHMKSNLTSPQTVPRL---IDEIV 908

  Fly   185 VHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAE--FPLQDLNLQISGWDPTKSSQTLI 247
            ::..:...  ...||||::.|:|.|.||..||||||.:..  || ...|..|:||.......|
Human   909 INPHYNRR--RKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFP-PGRNCSIAGWGTVVYQGT-- 968

  Fly   248 TSTVKERNPAD--------CLNRYPSFR-SASQVCAGGQRKG-DTCAGISGSPVMGIMGSGVDEF 302
            |:.:.:.  ||        |..:.|.:. :.:.:|||.:..| |:|.|.||.|:|    ...:..
Human   969 TANILQE--ADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLM----CQENNR 1027

  Fly   303 VFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANL 339
            .||||:.|:|.: |.....||||.::..|:|||::.|
Human  1028 WFLAGVTSFGYK-CALPNRPGVYARVSRFTEWIQSFL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	4/12 (33%)
		Tryp_SPc	108..338	CDD:238113	78/247 (32%)
		Tryp_SPc	108..335	CDD:214473	76/244 (31%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554
		LDLa	229..263	CDD:238060
		CUB	270..376	CDD:278839
		MAM	387..547	CDD:214533
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060
		SR	723..816	CDD:214555	9/28 (32%)
		Tryp_SPc	829..1059	CDD:214473	76/247 (31%)
		Tryp_SPc	830..1061	CDD:238113	78/248 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910